Bekir Cinar, PhD
Bekir Cinar, PhD is a Faculty Research Scientist and Assistant Professor of Medicine at the Uro-Oncology Program of the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center.
Dr. Cinar's research is centered on signal transduction and gene expression mechanisms relevant to cancer progression and metastasis. Current research in Dr. Cinar's laboratory focuses on two major areas: (i) defining the molecular basis of cross-talk between androgenic/AR-PI3 kinase/PTEN/Akt/mTOR survival pathways and the pro-apoptotic Mst/hippo serine/threonine kinase signaling pathways and (ii) identifying molecular targets that regulate cell differentiation, survival, oncogenesis, and tumor metastasis in a lipid-raft-dependent and independent manner. Lipid rafts are cholesterol-enriched microdomains that have been implicated in signal transduction. Using the know-how from these studies, his laboratory hopes to develop new strategies for cancer therapy. Dr. Cinar's laboratory uses biochemical, molecular and cellular biology, genetic, genomics and proteomics approaches and imaging techniques employing cell culture systems, animal models and clinical samples to achieve his research goals.
Dr. Cinar earned his professional degree from Ankara University, Ankara, Turkey and his doctorate in Biochemistry and Molecular Genetics from the University of Virginia. He completed his postdoctoral training as a Department of Defense and American Urological Association Foundation fellow at Children's Hospital Boston and Harvard Medical School. Before joining the Cedars-Sinai Medical Center as a faculty member, Dr. Cinar worked as a staff scientist at Children's Hospital Boston and faculty/instructor at Harvard Medical School.
Selected Recent Publications
1) Cinar B., Fang PK., Luchtman M., Di Vizio D., Adam RM., Pavlova N., Rubin MA., Yelick PC., and Freeman MR., "The proapoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1", EMBO J., 26:4523-34 (2007)
2) Cinar B., Mukhopadhyay NK., Meng G., and Freeman MR., "Phosphoinositide 3-kinase-independent nongenomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains", J. Biol. Chem., 282:29584-593 (2007)
3) Cinar B., de Benedetti A., and Freeman MR., "Post-translational regulation of the androgen receptor by the mammalian target of rapamycin", Cancer Res., 65:2547-53 (2005)
4) Cinar B., Yeung F., Mayo MW., Freeman MR., Zhau HYE., and Chung LWK., "Identification of a negative regulatory cis-element in the enhancer core region of the prostate specific antigen (PSA) promoter: Implications for intersection of androgen receptor and nuclear factor-κB signaling in prostate cancer cells", Biochem. J., 379:421-31 (2004)