Leland W. K. Chung, PhD
Director and Professor
Leland W. K. Chung is a Professor of Medicine and Director of the Uro-Oncology Research Program at the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center.
Dr. Chung's research focuses on tumor-stroma interaction with the goals of defining the biology, imaging, and targeting of tumor microenvironment. His research is funded by the National Cancer Institute and the Department of Defense. Dr Chung has published over 300 scientific papers, reviews, book chapters, and edited several books.
Dr. Chung earned his bachelor's degree from National Taiwan University, a master's degree in biochemistry from Oregon State University and a doctorate in pharmacology from the University of Oregon Medical School. He then completed a postdoctoral fellowship in pharmacology and experimental therapeutics at Johns Hopkins University School of Medicine.
Selected Recent Publications
1. Sung SY, Hsieh CL, Law A, Zhau HE, Pathak S, Multani AS, Lim S, Coleman IM, Wu LC, Figg WD, Dahut WL, Nelson P, Lee JK, Amin MB, Lyles R, Johnstone PA, Marshall FF, Chung LWK. Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis. Cancer Res. 68(23):9996-10003, 2008. NIHMSID 264446
2. Yang X, Shi C, Tong R, Qian W, Zhau HE, Wang R, Zhu G, Cheng J, Yang VW, Cheng T, Henary M, Strekowski L, Chung LWK. Near IR heptamethine cyanine dyemediated cancer imaging. Clin Cancer Res. 16(10):2833-2844, 2010.
3. Zhang S, Zhau HE, Osunkoya AO, Iqbal S, Yang X, Fan S, Chen Z, Wang R, Marshall FF, Chung LWK, Wu D. Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells. Mol Cancer. 9:9, 2010. PMCID: PMC2820018
4. Huang WC, Zhau HE, Chung LWK. Androgen receptor survival signaling is blocked by anti-β2-microglobulin monoclonal antibody via a mitogen-activated protein kinase/lipogenic pathway in human prostate cancer cells. J of Biol Chem. 285(11): 7947-56, 2010. PMCID: PMC2832945
5. Josson S, Nomura T, Lin JT, Huang WC, Wu D, Zhau HYE, Zayzafoon M, Weizmann N, Gururajan M, Chung LWK. β2-Microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells. Cancer Res. 71: 2600-2610, 2011.