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Jang-Won Lee, PhD
Jang-Won Lee, PhD is a research scientist in Cedars-Sinai’s Department of Neurosurgery.
Dr. Lee’s research is focused on the mechanism of communication between the cancer stem cell (CSC) and its microenvironment in brain cancer, especially in glioblastoma multiforme. His focus is on learning how CSCs maintain self-renewal and mutipotency that brings the chaos of brain cancer, which is different from functions of neural stem cells (NSC), in the course of brain development. He is seeking molecular mechanisms to explain the stemness of CSCs in relation with the microenvironment, which mutually communicate and affect each other. Dr. Lee’s work extends further to identify normal NSCs from an alternative source in order to develop cellular disease models and apply patient specific stem cell therapy for neurological diseases.
Dr. Lee has published numerous peer reviewed journal articles and abstracts as well as a book chapter on the molecular targeting of cancer stem cells. He has been invited to speak about stem cell research at national and international meetings.
Dr. Lee earned his doctorate at the University of Connecticut in Storrs, Connecticut, where he made contributions to the field of stem cell research by successfully cloning live transgenic pigs. During his postdoctoral training at Harvard and Wake Forest Institute Regenerative Medicine, he continued to pursue developing patient-specific stem cells and combining stem cells and tissue engineering.
Key Words: Cancer stem cells, Neural stem cells, Microenvironment, Neurological diseases, Cell therapy, Cellular disease models