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Wen-Chin Huang, PhD
Wen-Chin Huang is an Assistant Professor and a Research Scientist I in the Uro-Oncology Research Program at the Samuel Oschin Comprehensive Cancer Institute of Cedars-Sinai Medical Center.
Dr. Huang's research focuses on biochemistry, molecular biology, cell biology, and cancer signaling transduction. His work has shown that a small molecule, β2-microglobulin (β2M), plays multiple biological roles in prostate cancer growth, survival, progression and metastasis. He also found that targeting β2M using a small interfering RNA and an immuno-antibody against human β2M greatly induced the programmed cell death of prostate cancer cells. His research is funded by the Department of Defense. He was the recipient of a young investigator award from the Georgia Cancer Coalition.
Dr. Huang earned his PhD degree from National Taiwan University, Taiwan. He then completed a postdoctoral fellowship in the Department of Urology at the Emory University School of Medicine.
Selected Recent Publications
Li, X., Chen, Y.T., Josson, S., Mukhopadhyay, N.K., Kim, J., Freeman, M.R. and Huang, W.C. MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer. PLoS ONE, 2013.
Huang, W.C., Li, X., Liu, J., Lin, J. and Chung, L.W. Activation of androgen receptor, lipogenesis and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells. Mol Cancer Res, 10: 133-42, 2012.
Josson, S., Nomura, T., Lin, J., Huang, W.C., Wu, D, Zhau, H.E., Zayzafoon, M., and Chung, L.W. b2-Microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells. Cancer Res, 71: 2600-10, 201.
Huang, W.C., Zhau, H.E. and Chung, L.W. Androgen receptor survival signaling is blocked by anti-b2-microglobulin monoclonal antibody via a MAPK/lipogenic pathway in human prostate cancer cells. J Biol Chem, 285:7947-59, 2010.
Huang, W.C., Havel, J. J., Zhau, H.E., Qian, W.P., Lue, H., Chu C., Nomura, T. and Chung, L.W. b2-Microglobulin signaling blockade inhibited androgen receptor axis and caused apoptosis in human prostate cancer cells.Clin Cancer Res, 14: 5341-7, 2008.