Wen-Chin Huang, PhD

Assistant Professor

Wen-Chin Huang is an Assistant Professor and a Research Scientist I in the Uro-Oncology Research Program at the Samuel Oschin Comprehensive Cancer Institute of Cedars-Sinai Medical Center.

Dr. Huang's research focuses on biochemistry, molecular biology, cell biology, and cancer signaling transduction. His work has shown that a small molecule, β2-microglobulin (β2M), plays multiple biological roles in prostate cancer growth, survival, progression and metastasis. He also found that targeting β2M using a small interfering RNA and an immuno-antibody against human β2M greatly induced the programmed cell death of prostate cancer cells. His research is funded by the Department of Defense. He was the recipient of a young investigator award from the Georgia Cancer Coalition.

Dr. Huang earned his PhD degree from National Taiwan University, Taiwan. He then completed a postdoctoral fellowship in the Department of Urology at the Emory University School of Medicine.


Selected Recent Publications

  • Li, X., Chen, Y.T., Josson, S., Mukhopadhyay, N.K., Kim, J., Freeman, M.R. and Huang, W.C. MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer. PLoS ONE, 2013.

  • Huang, W.C., Li, X., Liu, J., Lin, J. and Chung, L.W. Activation of androgen receptor, lipogenesis and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells. Mol Cancer Res, 10: 133-42, 2012.

  • Josson, S., Nomura, T., Lin, J., Huang, W.C., Wu, D, Zhau, H.E., Zayzafoon, M., and Chung, L.W. b2-Microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells. Cancer Res, 71: 2600-10, 201.

  • Huang, W.C., Zhau, H.E. and Chung, L.W. Androgen receptor survival signaling is blocked by anti-b2-microglobulin monoclonal antibody via a MAPK/lipogenic pathway in human prostate cancer cells. J Biol Chem, 285:7947-59, 2010.

  • Huang, W.C., Havel, J. J., Zhau, H.E., Qian, W.P., Lue, H., Chu C., Nomura, T. and Chung, L.W. b2-Microglobulin signaling blockade inhibited androgen receptor axis and caused apoptosis in human prostate cancer cells.Clin Cancer Res, 14: 5341-7, 2008.