Serhan Alkan, MD
Vice Chair, Director of Clinical Pathology
Director, Academic Clinical Pathology
Professor of Pathology
Director, Hematopathology Fellowship
Director, Personalized Medicine Diagnostics
Clinical Specialty: Hematopathology
Education and Training
- Ege Medical University, Izmir, Turkey; MD
- Residency in Anatomic and Clinical Pathology, George Washington University, Washington DC
- Fellowship in Hematopathology, University of Michigan Medical Center, Ann Arbor, MI
Medical Board Certification
- Board Certified, Anatomic Pathology
- Board Certified, Clinical Pathology
- Board Certified, Hematopathology
Clinical and Research Interests
- Use of immunohistochemical and molecular markers in assessment of hematopoietic neoplasms
- Analysis of intracellular signaling molecules that regulate survival of neoplastic cells
Awards and Activities
- Described use of proteosome inhibitors as an effective therapy in treatment of multiple myeloma
- Demonstrated potential use of Histone deacetylase inhibitors in treatment of leukemias and multiple myeloma
- Meyer PN, Roychowdhury S, Kini AR, Alkan S. HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells. Leuk Res 2008;32(1):143-9.
- Ozpuyan F, Meyer P, Ni H, Almasri H, Alkan S. Bortezomib Induces Apoptosis in T Cell Prolymphocytic Leukemia (T-PLL). Leukemia Lymphoma 2007; 48(11): 2247-50.
- Venkataraman G, Maududi T, OzPuyan F, Bahar IH, Izban KF, Qin JZ, Alkan S. Induction of Apoptosis and Down Regulation of Cell Cycle Proteins in Mantle Cell Lymphoma by Flavopiridol Treatment. Leuk Res 2006;30(11):1377-84.
- Alkan S, Huang Q , Ergin M, Denning MF, Nand S, Maududi T, Paner GP, Ozpuyan F, Izban KF. Survival Role of Protein Kinase C (PKC) in Chronic Lymphocytic Leukemia and Determination of Isoform Expression pattern and Genes Altered By PKC Inhibition. Am J Hematol 2005;79:97–106.
- Ni H, Ergin M, Huang Q, Qin JZ, Amin HM, Martinez RL, Saeed S, Barton K, Alkan S. Analysis of NF-kappa B expression in multiple myeloma (MM): Down-regulation of NF-kappa B induces apoptosis in MM. Brit J Haematol 2001;115(2):279-86.
- Amin HM, Saeed S, Alkan S. Histone deacetylase inhibitors induce caspase-dependent apoptosis and down regulation of daxx in acute promyelocytic leukemia with t(15;17). Brit J Haematol 2001;115(2):287-97.
Click here for a list of peer-reviewed publications by Serhan Alkan, MD.