Clinical Electrophysiology: Research

Atrial Fibrillation Research Program

The World Health Organization Global Burden of Atrial Fibrillation Panel

Atrial fibrillation is the most common arrhythmia diagnosis around the globe. This panel is charged with evaluating the burden of atrial fibrillation in the WHO's 21 regions of the world. Headed by Dr. Sumeet Chugh (Cedars-Sinai Heart Institute), panel members are Dr. Emelia Benjamin (Framingham Heart Study), Dr. Zhi-Jie Zheng (National Heart, Lung and Blood Institute), Dr. Richard Gillum (U.S. CDC) and Dr. George Mensah (U.S. Centers for Disease Control and Prevention).

Multi-Center Trials Evaluating Novel Treatment Modalities for Heart Rhythm Disorders

Faculty members of the Electrophysiology Section continue to participate in multiple, ongoing research trials that evaluate newly developed modalities for arrhythmia management.

The Cardiac Arrest Prevention Program

Researchers in the Cardiac Arrest Prevention Program at Cedars-Sinai are working to enhance the understanding of mechanisms of sudden cardiac arrest. Despite current advances, the rate of successful resuscitation from sudden cardiac arrest remains low. Our group is searching for novel determinants of this condition that will facilitate the identification of subjects at risk, with the overall goal of improving prevention of sudden cardiac arrest.

The Cardiac Arrest Prevention Program is involved in a variety of ongoing studies at Cedars-Sinai Medical Center and Oregon Health & Science University, as well as several national and international collaborative efforts. The Oregon Sudden Unexpected Death Study, initiated and led by Dr. Sumeet Chugh and now in its eighth year, is being conducted in collaboration with the Department of Emergency Medicine at Oregon Health & Science University.

The Oregon Sudden Unexpected Death Study

This research effort, currently funded by the National Heart, Blood and Lung Institute, as well as a collaborative grant with the Johns Hopkins Reynolds Cardiovascular Clinical Research Center, is an investigation of sudden cardiac arrests that occur among residents of the Portland, Oregon, metropolitan area. A novel and comprehensive approach of clinical, epidemiologic, environmental, genetic and proteomic analysis is employed to extend and enhance risk stratification and prevention of sudden cardiac death.

Researchers

  • Sumeet Chugh, MD, Associate Director for Genomic Cardiology, the Heart Institute; Section Chief, Clinical Electrophysiology; Price Endowed Chair in Electrophysiology Research, Cedars-Sinai Medical Center; Principal Investigator
  • Jonathan Jui, MD, Professor of Emergency Medicine, Oregon Health & Sciences University,
    Co-Investigator
  • Subhashish Chakravarty, PhD, Research Biostatistician
  • Audrey Uy-Evanado, MD, Research Associate
  • Adriana Huertas-Vaszuez, PhD, Research Scientist I
  • Dong Li, MD, PhD, Research Scientist I
  • Ron Mariani, EMT-P, Research Associate
  • Jo Navarro, BS, Research Assistant
  • Kyndaron Reinier, PhD, MPH, Research Scientist I
  • Eric Stecker, MD, MPH, Collaborator; Assistant Professor, Cardiology Division, Oregon Health & Sciences University
  • Carmen Teodorescu, MD, Post Doctoral Fellow

Selected Recently Published Papers

Chugh SS, Whitesel S, Roberts C, Nagalla S. Genetic basis for chamber-specific ventricular phenotypes in the rat infarct model. Cardiovasc Res 2003; 57(2): 477-85

Chugh SS, Chung K, Zheng Z-J, John B, Kelly K, Titus JL. Cardiac Pathologic Findings Reveal High Rate of Sudden Cardiac Death of Undetermined Etiology in Younger Women. Am Heart J 2003; 146(4): 635-639

Dogra V, Oliver R, Lapidus J, Balaji S, Kron J, McAnulty J, Chugh SS. Apparent Protective Effect of Increased Left Ventricular Wall Thickness in an ICD Population. J Cardiac Failure 2003; 9(5): 412-415

Chugh SS, Senashova O, Watts A, Tran PT, Zhou Z, Gong Q, Titus JL and Hayflick SJ. Postmortem Molecular Screening in Unexplained Sudden Death. J Am Coll Cardiol 2004; 43(9):1625-1629

John B, Titus JL, Edwards WD, Shen W-K, Chugh SS. Global Remodeling of the Ventricular Interstitium in Idiopathic Myocardial Fibrosis and Sudden Cardiac Death. Heart Rhythm 2004; 1: 141-149.

Arking D, Chugh SS, Chakravarti A, Spooner PM. Genomics in Sudden Cardiac Death. Circulation Research 2004. 94(6): p. 712-723.

Chugh SS, Jui J, Gunson K, Stecker EC, John BT, Thompson B, Ilias N, Vickers C, Dogra V, Daya M, Kron J, Zheng Z-J, Mensah G, McAnulty J. Current Burden of Sudden Cardiac Death: Multiple Source Surveillance Versus Retrospective Death Certificate-Based Review in a Large US Community. J Am Coll Cardiol 2004; 44(6): 1268-75

Stecker EC, Strelich KR, Chugh SS, Crispell K, McAnulty JH. Arrhythmias after orthotopic heart transplantation. J Card Fail 2005;11(6):464-72.

Raitt MH, Connor WE, Morris C, Kron J, Halperin B, Chugh SS, et al. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA 2005;293(23):2884-91.

TStecker EC, Vickers C, Waltz J, Socoteanu C, John BT, Mariani R, McAnulty JH, Gunson K, Jui J, Chugh SS. Population-based analysis of sudden cardiac death with and without left ventricular systolic dysfunction: two-year findings from the Oregon Sudden Unexpected Death Study. J Am Coll Cardiol 2006;47(6):1161-6.

Stecker EC, Sono M, Wallace E, Gunson K, Jui J, Chugh SS. Allelic Variants of SCN5A and risk of sudden cardiac arrest in patients with coronary artery disease. Heart Rhythm 2006;3(6):697-700

Reinier K, Stecker EC, Vickers C, Gunson K, Jui J, Chugh SS. Incidence of sudden cardiac arrest is higher in areas of low socioeconomic status: A prospective two year study in a large United States community. Resuscitation 2006;70(2):186-92

Stecker EC, Zargarian M, Dogra V, John BT, Kron J, McAnulty JH, Chugh SS. Native QRS Duration Predicts the Occurrence of Arrhythmic Events in ICD Recipients. Europace 2006;8(10):859-62

Kehr E, Sono M, Chugh SS, Jerosch-Herold M. Gadolinium-Enhanced Magnetic Resonance Imaging for Detection and Quantification of Fibrosis in Human Myocardium In-Vitro. International Journal of Cardiovascular Imaging 2007; 49(25):2416-8

Chugh SS, Socoteanu C, Reinier K, Waltz J, Jui J, Gunson K. A Community-Based Evaluation of Sudden Death Associated with Therapeutic Levels of Methadone. Am J Med 2008;121:66-71.

Chugh SS, Reinier K, Teodorescu C, Evanado A, Kehr E, Al Samara M, Mariani R, Gunson K, Jui J. Epidemiology of Sudden Cardiac Death: Clinical and Research Implications. Progress in Cardiovascular Diseases 2008;51(3):213-28.

Reddy PR, Reinier K, Singh T, Mariani R, Gunson K, Jui J, Chugh SS. Physical activity as a trigger of sudden cardiac arrest: The Oregon Sudden Unexpected Death Study. Int J Cardiol. 2009;131(3):345-9

Chugh SS, Reinier K, Singh T, Evanado A, Socoteanu C, Peters Dawn, Mariani R, Gunson K, Jui J. Determinants of Prolonged QT Interval and Their Contribution to Sudden Death Risk in Coronary Artery Disease: The Oregon Sudden Unexpected Death Study. Circulation 2009;119:663-670.