Aortic Clinical Trials

Cedars-Sinai Heart Institute is currently conducting the following Aortic trials:

Talent descending thoracic aortic aneurysm endovascular repair post-approval study (THRIVE Trial)

Principal Investigator: Ali Khoynezhad, MD
IRB Approval Number: 23873
Contact: Laura Sarmiento: (310) 423-4295
Status: Enrolling

Summary:
The THRIVE trial is a post-marketing-approval study for Medtronic Talent stent graft. The patients with thoracic aortic aneurysm and penetrating aortic ulcer are enrolled in this trial, who are treated by endovascular means using the Talent Thoracic stent graft. They are followed for up to five years after the index operation with physical exam, CT scans, laboratory work and chest x-rays. The goal is to evaluate the mid-term outcome of this patient population, and to investigate any device-specific complications.


Medtronic Valiant stent graft for complicated acute type B aortic dissection

Principal Investigator
: Ali Khoynezhad, MD
IRB Approval Number: 23873
Contact: Laura Sarmiento: (310) 423-4295
Status: Enrolling

Summary:
The Valiant dissection study is a phase III stent graft trial. The patients with complicated acute type B aortic dissection are enrolled in this trial, who are treated by endovascular means using the Valiant Thoracic stent graft. They are followed for up to five years after the index operation with physical exam, CT scans, laboratory work and chest x-rays. The goal is to evaluate the mid-term outcome of this patient population, and to investigate any device-specific complications.


Medtronic Valiant stent graft for aortic transection (RESCUE Trial)

Principal Investigator:
Ali Khoynezhad, MD
IRB Approval Number: 25260
Contact: Laura Sarmiento: (310) 423-4295
Status: Enrolling

Summary:
The RESCUE trial is a phase III trial for Medtronic Valiant stent graft. The patients with aortic transection are enrolled in this trial, who are treated by endovascular means using the Valiant Thoracic stent graft. They are followed for up to five years after the index operation with physical exam, CT scans, laboratory work and chest x-rays. The goal is to evaluate the mid-term outcome of this patient population, and to investigate any device-specific complications.