Quantitative Blood Pool SPECT (QBS)

Overview

QBS (Quantitative Blood Pool SPECT) is an interactive standalone application for the automatic segmentation and quantification of gated short axis blood pool (red blood cells, RBC), SPECT.

New Features

The following features have recently been added to the software:

  • Regional histogram-based phase calculations with several measures of inter- and intra-ventricular synchrony (mean, mode, standard deviation, full width at 10th of the maximum, and entropy).
  • Improved manual mode for complete control of the ventricular segmentation.
  • Optional OpenGL-based hardware acceleration of the 3D displays for improved performance.

In Depth

The following basic functionality is still available:

  • Automatic generation of left- and right-ventricular endocardial surfaces and valve planes from three-dimensional (3D) gated short axis blood pool images.
  • Automatic calculation of left- and right-ventricular volumes and ejection fractions.
  • Two-dimensional (2D) image display using standard American College of Cardiology (ACC) cardiac SPECT conventions.
  • 3D image display. Ability to combine isosurfaces extracted from the data with the calculated endocardial surfaces in various ways (endocardial borders displayed as wireframes, shaded surfaces or both).
  • Display of projection (raw) images in static and cine mode. Two-dimensional display of gated short axis SPECT images in 1 (single), 2 (dual), 3 (triple), or 4 (quadruple) mode. (2, 3, and 4 are displayed as interleaved or side-by-side). Three-dimensional parametric display of gated short axis SPECT images in 1 (single), 2 (dual), 3 (triple), or 4 (quadruple) mode. (2, 3, and 4 are displayed as interleaved or side-by-side
  • Display of planar images, raw projection images and snapshots (screen captures).
  • Ability to support manual identification of the left-ventricular (LV) region, to separate it from the right ventricle (RV) in cases where the automatic algorithm fails or returns unsatisfactory results.
  • Calculation of phase histograms from all gated images, including separate left-ventricular (LV) and right-ventricular (RV) histograms based on the program¿s ROIs for gated short axis SPECT images.
  • Calculation and display of first Fourier harmonic (FFH) amplitude and phase images for all gated images.
  • Computation of diastolic function metrics for the left and right ventricles including PER (peak emptying rate), PFR (peak filling rate), PFR2 (secondary peak filling rate), MFR/3 (mean filling rate over the first third of the ED to ES phase), and TTPF (time to peak filling from ES). HR (heart rate in beats per minute) is also displayed if available.
  • Ability to rotate, zoom and cine surfaces.
  • Calculation and display of polar maps representing wall motion, including FFH amplitude and phase.

Screenshots

(Click on an image to enlarge.)

Software Availability

Information regarding the availability of QBS can be found here.

Publications

(Note: The first two references describe the initial version of this application.)

  • Van Kriekinge SD, Berman DS, Germano G. Automatic quantification of left ventricular ejection fraction from gated blood pool SPECT. Circulation, 1997 (abstract); :I-309.
  • Van Kriekinge SD, Berman DS, Germano G. Automatic quantification of left ventricular ejection fraction from gated blood pool SPECT. Journal of Nuclear Cardiology, 1999 6(5): pp. 498-506.
  • Van Kriekinge SD, Berman DS, Germano G. Automatic quantification of left and right ventricular ejection fractions from gated blood pool SPECT. Circulation, 1999 (abstract). 100(18): p. I-26.
  • Van Kriekinge SD et al. Validation of quantitative left-ventricular end-diastolic and end-systolic volumes from gated blood pool SPECT. Journal of the American College of Cardiology, 2001 (abstract). 37(2): p. 500A
  • Daou D, et al. Left ventricular function estimated with ECG-gated blood pool SPECT: Comparison of two different processing softwares. Journal of Nuclear Medicine, 2001 (abstract). 42(5): p. 137P.
  • Vanhove C, et al. Comparison between two automatic algorithms to determine left ventricular volumes and ejection fraction from gated blood pool tomography. Journal of Nuclear Medicine, 2001 (abstract). 42(5): p. 167P.
  • Vanhove C, et al. Left ventricular ejection fraction and volumes from gated blood pool tomographies: A comparison between two automatic algorithms. European Journal of Nuclear Medicine, 2001 (abstract). 28(8) p. OS298.
  • Vanhove C and Franken PR. Left ventricular ejection fraction and volumes from gated blood pool tomography: Comparison between two automatic algorithms that work in three-dimensional space. Journal of Nuclear Cardiology, 2001. 8(4): pp. 466-471.
  • Vanhove C et al. Gated myocardial perfusion tomography versus gated blood pool tomography for the calculation of left ventricular volumes and ejection fraction. European Journal of Nuclear Medicine and Molecular Imaging, 2002. 29(6): pp 735-741.
  • Schwartz R et al. Blood pool gated SPECT: Validation of left ventricular volumes and ejection fraction with planar radionuclide angiography. Journal of Nuclear Cardiology, 2000 (abstract). 7(4):p. S2.
  • Keng F, T Chua and T Koh. Quantitative blood pool single-photon emission computed tomography (QBS) program: Comparison with conventional planar equilibrium blood pool imaging (MUGA). Journal of Nuclear Cardiology, 2003 (abstract). 10(1): p. S25.
  • Alexanderson E et al. Assessment of ventricular perfusion and function with nuclear scan and echocardiography in patients with corrected transposition of great arteries. Journal of Nuclear Cardiology, 2003 (abstract). 10(1) p. S66.
  • Daou D. Automatic calculation of right ventricular ejection fraction with gated blood pool SPECT: A clinical validation study. Journal of Nuclear Medicine, 2002 (abstract). 43(5): p. 97P.
  • Nakajima K et al. Quantitative gated SPECT with myocardial perfusion and blood-pool studies to determine ventricular volumes and stroke volume ratio in congenital heart diseases. Journal of Nuclear Cardiology, 2003 (abstract). 10(1): p. S11.
  • Keng F et al. Quantitative blood pool single photon emission computed tomography (QBS) Program: comparison to Cardiac Magnetic Resonance Imaging (CMR). Journal of Nuclear Cardiology, 2003 (abstract). 10(1) p. S5.
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