Neural Stem Cells

Principal Investigator: Dwain Morris-Irvin, PhD, MPH

Dr. Morris-Irvin’s research group focuses on identifying novel therapeutics for the treatment of brain tumors.  More specifically, the lab is focused on developing novel vaccines for the prevention of brain tumors and tumor recurrence.  The lab focuses on improving the efficacy of dendritic cell immunotherapy through the use of pharmacological adjuvants and identifying novel immunotargets for combinatorial therapies.  Recently, specialized populations of tumor cells, referred to as cancer stem cells, have been shown to have the potential to generate tumors and/or provide resistance to common therapies including chemotherapy and radiation therapy.  Furthermore, these resistant cancer cells may also provide resistance to immunotherapy or endogenous anti-tumor immune responses.  Dr. Morris-Irvin’s lab characterizes these specialized cancer cells and identifies signaling systems and proteins used by these specialized cells to impart resistance to therapies.  Subsequently, the lab targets these pathways for inhibition in order to make the putative cancer stem cells more sensitive to standard and immunotherapy. 

Selected Publications:

Patil C, Yi A, Elramsisy A, Hu J, Mukherjee D, Irvin D, Yu J, Bannykh S, Black K, Nuño M. Prognosis of Patients with Multifocal Glioblastoma: A Case-Controlled Study. 2012.  Journal of Neurosurgery

Irvin DK, Jouanneau E, Duvall G, Zhang X, Zhai y, Sarayba D, Seksenyan A, Panwar A, Black KL, Wheeler CJ. T cell activity promotes stem-like properties, but not malignancy, in gliomas. 2010, PlosOne, Jun 7;5(6):e10974.

Yin D, Wang X, Konda B, Ong J, Hu J, Sacapano M, Ko M, Espinoza A, Irvin DK, Shu Y, Black K. Increase in Brain Tumor Permeability in Glioma-bearing Rats with Nitric Oxide Donors. Clinical Cancer Research, 14(12): 4002-9, 2008.

Irvin DK, Thompson L, Kirik D, Björklund A In Vivo Gene Delivery to Endogenous Striatal Progenitors Generated by a 6-hydroxydopamine Lesion of the Nigrostriatal Dopamine Pathway. In Press, Neurobiology of Disease. 2008.

Wheeler C, Black K, Liu G, Wagenberg M, Zhang X, Pepkowitz S, Goldfinger D, Ng H, Irvin DK, Yu J. Vaccination with tumor lysate-pulsed dendritic cells elicits correlated immune and clinical response magnitudes in patients with glioblastoma multiforme. Cancer Research, 68(14): 5955-64, 2008.

Ghods-Jourabchi A, *Irvin DK, Gentao Liu G, Abdulkadir I, Yuan X, Tunici P, Wachsmann-Hogi S, Konda B, Black K, Yu J, Spheres Isolated from 9L Gliosarcoma Rat Cell Line Possess Chemoresistant and Aggressive Cancer Stem-Like Cells. Stem Cells. July, 2007.

Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, Lu L, Irvin DK, Black KL, Yu JS. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Molecular Cancer. 2006 Dec 2; 5:67.

Andersson E, Irvin DK, Ahlsiö J Parmar M. Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells. Experimental Cell Research. December, 2006.

Irvin DK, Yuan X, Tunici P, Yu JS. Neural Stem Cells: A Promising Potential Therapy for Brain Tumors. Current Stem Cell Research & Therapy. Vol.1, 2006.

Tunici P, Irvin DK, Liu G, Yuan X, Zhaohui Z, Ng H, Yu J, Brain Tumor Stem Cells: New Targets for Clinical Treatments. Neurosurgical Focus 20(4) E27, 2006.

Irvin D, Yu JS Stem Cells A Potential Therapy for Brain Tumors. NeuroReport 2006.

Irvin DK, Nakano I, Paucar AA, Kornblum HI. Patterns of Jagged1, Jagged2,       Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggests multiple functional roles in progenitors and differentiated cells. 2004 Journal of Neuroscience Research 75(3): 330-4

Irvin DK, Dhaka A, Hicks C, Weinmaster G, Kornblum HI. Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures. 2003 Developmental Neuroscience 25(2-4):162-72.

Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. 2003 Developmental Biology 264(2): 309-22.

Dhaka A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J. The RAS effector RIN1 modulates the formation of aversive memories. 2002 Journal of Neuroscience 23(3):748-57.

Kinoshita Y, Jarell AD, Flaman JM, Foltz G, Schuster J, Sopher BL, Irvin DK, Kanning K, Kornblum HI, Nelson PS, Hieter P, Morrison RS. Pescadillo, a novel  cell cycle regulatory protein abnormally expressed in malignant cells. 2001 Journal of Biological Chemistry 276(9): 6656-65.

Irvin DK, Zurcher SD, Nguyen T, Weinmaster G, Kornblum HI. Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development. 2001 Journal of Comparative Neurology 436(2): 167-81.

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