Research Publications


Huang WC., Zhau HE., and Chung LW., "Androgen receptor survival signaling is blocked by anti-β2-microglobulin monoclonal antibody via a mitogen-activated protein kinase/lipogenic pathway in human prostate cancer cells", JBC, In Press (2010)

He H., Yang X-J., Davidson AJ., Wu D., Marshall FF., Chung LWK., Haiyen HYE., and Wang R-X., "Progressive Epithelial to Mesenchymal Transitions in ARCaPE Prostate Cancer Cells During Xenograft", The Prostate, In press (2010)

He H., Xu J., Nelson P., Marshall FF., Chung LWK., Haiyen HYE., He DL., Wang R-X., "Differential expression of the α2 chain of the interleukin-13 receptor in metastatic human prostate cancer ARCaPM cells", The Prostate, In press (2010)

Zhang SM., Zhau HYE., Osunkoya AO., Iqbal S., Yang XJ., Fan SQ., Chen ZJ., Wang RX., Marshall FF., Chung LWK., and Wu DQ., "Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells", Molecular Cancer, In press (2010)



Josson S., Matsuoka Y., Chung LWK., Zhau HE., and Wang R., "Tumor stoma co-evolution in prostate cancer progression and metastasis", Seminars in Cell and Developmental Biology, Dec. 3, Epub. (2009)

Singh S., Singh R., Sharma PK., Singh UP., Rai SN., Chung LWK., Cooper CR., Novakovic KR., Grizzle WE., and Lillard JW. Jr., "Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion", Cancer Letter, 283: 29-35 (2009)

Zhu Y., Su Y., Cheng T., Chung LWK., and Shi C., "Beta2-microglobulin as a potential factor for the expansion of mesenchymal stem cells", Biotech Letter, 31: 1361-65 (2009)

Thalmann GN., Rhee H., Sikes RA., Pathak S., Multani A., Zhau HE., Marshall FF., and Chung LWK., "Human Prostate Fibroblasts Induce Growth and Confer Castration Resistance and Metastatic Potential in LNCaP Cells", Eur Urol., Sep. 4, Epub. (2009)

Wang R., He H., Sun X., Xu J., Marshall FF., Zhau H., Chung LWK., Fu H., and He D., "Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins", Biochem Biophys Res Commun, 389: 455-60 (2009)

Singh R., Singh UP., Rai SN., Novakovic KR., Chung LWK., Didier PJ., Grizzle WE., and Lillard JW. Jr., "Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines", Int J Cancer, 125: 2288-95 (2009)

Shigemura K., Isotani S., Wang R., Fujisawa M., Gotoh A., Marshall FF., Zhau HE., and Chung LWK., "Soluble factors derived from stroma activated androgen receptor phosphorylation in human prostate LNCaP cells: roles of ERK/MAP kinase", The Prostate, 69: 949-55 (2009)

Shi C., Zhu Y., Xie Z., Qian W., Hsieh CL., Nie S., Su Y., Zhau HE., and Chung LWK., "Visualizing human prostate cancer cells in mouse skeleton using bioconjugated near-infrared fluorescent quantum dots", Urology, 74: 446-51 (2009)

Shi C., Zhu Y., Su Y., Chung LWK., and Cheng T., "Beta2-microglobulin: emerging as a promising cancer therapeutic target", Drug Discov Today, 14: 25-30 (2009)

Arnold RS., Sun CQ., Richards JC., Grigoriev G., Coleman IM., Nelson PS., Hsieh CL., Lee JK., Xu Z., Rogatko A., Osunkoya AO., Zayzafoon M., Chung LWK., and Petros JA., "Mitochondrial DNA mutation stimulates prostate cancer growth in bone stromal environment", Prostate, 69: 1-11 (2009)

Graham TR., Odero-Marah VA., Chung LWK, Agrawal KC., Davis R., and Abdel-Mageed AB., "PI3K/Akt-dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells", Prostate, 69: 168-80 (2009)

Mukhopadhyay NK., Kim J., Cinar B., Ramachandran A., Hager M., Adam RM., Raychaudhuri P., De Benedetti A., and Freeman MR., "Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation", Cancer Res., 69:2210-8 (2009)

Phan JH., Moffitt RA., Stokes TH., Liu J., Young AN., Nie S., and Wang MD., "Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment", Trends in Biotechnology, 27(6): 350-8 (2009)

Xu* Y., Josson* S., Fang F., Oberley TD., Clair DK., Wan SX., Sun Y., Bakthavatchalu V., Muthuswamy A., and Clair WH.. "RelB Enhances Prostate Cancer Growth: Implications for the Role of the NF-kappa B Alternative Pathway in Tumorigenicity", Cancer Res, 69(8):3267-71 (2009) * Co-first author



Sung SY., Hsieh CL., Law A., Zhau HE., Pathak S., Multani AS., Lim S., Coleman IM., Wu LC., Figg WD., Dahut WL., Nelson P., Lee JK., Amin MB., Lyles R., Johnstone PA., Marshall FF., and Chung LWK., "Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis", Cancer Res., 68(23):9996-10003 (2008)

Shi C., Wang X., Wu S., Zhu Y., Chung LWK, and Mao H., "HRMAS (1)H-NMR measured changes of the metabolite profile as mesenchymal stem cells differentiate to targeted fat cells in vitro: implications for non-invasive monitoring of stem cell differentiation in vivo", J Tissue Eng Regen Med., (8):482-90 (2008)

Huang WC., Havel JJ., Zhau HE., Qian WP., Lue HW., Chu CY., Nomura T., and Chung LWK., "β2-Microglobulin signaling blockade inhibited androgen receptor axis and caused apoptosis in human prostate cancer cells", Clin Cancer Res., 14: 5341-7 (2008)

Seo SI., Gera L., Zhau HE., Qian W-P., Iqbal S., Johnson NA., Zhang S., Zayzafoon M., Stewart J., Chung LWK, and Wu D., "BKM1740, an acyl-tyrosine bisphosphonate amide derivative, inhibits the bone metastatic growth of human prostate cancer cells through the inhibition of survivin expression", Clinical Cancer Res., 14(17):5341-7 (2008)

Josson S., Sung SY., Lao K., Chung LWK, and Johnstone PA., "Radiation modulation of MicroRNA in prostate cancer cell lines", Prostate, 68(15):1599-606 (2008)

Zhau HE., Odero-Marah V., Lue HW., Nomura T., Wang R., Chu G., Huang WC., and Chung LWK., "Epithelial to Mesenchymal Transition (EMT) in Human Prostate Cancer: Lessons Learned from ARCaP Model", Clinical and Experimental Metastasis, 25 (6):601-10 (2008)

Shi C., Zhu Y., Zhou G., Su Y., Cheng T., Zhau HE., and Chung LWK. "Multiplexing semiconductor quantum dot-based detection of protein expression in human prostate cancer cells", European Journal of Histochemistry, 52: 127-33 (2008)

Odero-Marah V., Wang R., Chu G., Xu J., Shi C., Marshall FF., Zhau HE., and Chung LWK., "Receptor activator of NFkB ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells", Cell Research, 18(8):858-70 (2008)

Shi C., Zhu Y., Cerwinka WH., Zhau HE., Marshall FF., Simons JW., Nie S., and Chung LWK. "Quantum dots: emerging applications in urologic oncology", Urol Oncol., 26(1):86-92 (2008)

Pienta KJ., Abate-Shen C., Agus DB., Attar RM., Chung LWK, Greenberg NM., Hahn WC., Isaacs JT., Navone NM., Peehl DM., Simons JW., Solit DB., Soule HR., Vandyke TA., Weber MJ., Wu L., and Vessella RL., "The current state of preclinical prostate cancer animal models", Prostate, 68(6):629-39 (2008)

Shi C., Zhou G., Zhu Y., Su Y., Cheng T., Zhau HYE., and Chung LWK., "Quantum dots-based multiplexed immunohistochemistry of protein expression in human prostate cancer cells", Eu. J. Histochemistry, 52: 127-33 (2008)

Xu Y., Fang F., Clair DK., Sompol P., Josson S., and Clair WH., "SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation", Mol Cancer Ther, 7(8):2367-76 (2008)



Shirakawa T., Terao S., Hinata N., Tanaka K., Takenaka A., Hara I., Sugimura K., Matsuo M., Hamada K., Fuji K., Okegawa T., Higashihara E., Gardner TA., Kao C., Chung LWK, Kamidono S., Fujisawa M., and Gotoh A., "Long-term outcome of phase I/II clinical trial of Ad-OC-TK/VAL gene therapy for hormone-refractory metastatic prostate cancer", Hum Gene Ther., 18(12):1225-32 (2007)

Wang R., Xu J., Mabjeesh N., Zhu G., Zhou J., Amin M., He D., Marshall FF., Zhau HE., and Chung LWK., "PrLZ is expressed in normal prostate development and in human prostate cancer progression", Clin Cancer Res., 13(20):6040-8 (2007)

Zhang H., Wang J., Pang B., Liang RX., Li S., Huang PT., Wang R., Chung LWK, Zhau HE., Huang C., and Zhou JG., "PC-1/PrLZ Contributes to Malignant Progression in Prostate Cancer", Cancer Res., 15;67(18):8906-13 (2007)

Yuan K., Chung LWK., Siegal GP., and Zayzafoon M., "Alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression", Lab Invest., 87(9):938-50 (2007)

Mukhopadhyay NK., Cinar B., Mukhopadhyay L., Lutchman M., Ferdinand AS., Kim J., Chung LWK., Adam RM., Ray SK., Leiter AB., Richie JP., Liu BC., and Freeman MR., "The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer", Mol Endocrinol., 21(9):2056-70 (2007)

Xing Y., Chaudry Q., Shen C., Kong KY., Zhau HE., Chung LWK., Petros JA., O'Regan RM., Yezhelyev MV., Simons JW., Wang MD., and Nie S., "Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry", Nat Protoc., 2(5):1152-65 (2007)

Nomura T., Huang WC., Seo S., Zhau HE., Mimata H., and Chung LWK., "Targeting beta2-microglobulin mediated signaling as a novel therapeutic approach for human renal cell carcinoma", J Urol., 178(1):292-300 (2007)

Sung SY., Hsieh CL., Wu D., Chung LWK, and Johnstone PA., "Tumor microenvironment promotes cancer progression, metastasis, and therapeutic resistance", Curr Probl Cancer, 231(2):36-100 (2007)

Hsieh CL., Xie Z., Yu J., Martin WD., Datta MW., Wu GJ., and Chung LWK., "Non-invasive bioluminescent detection of prostate cancer growth and metastasis in a bigenic transgenic mouse model", Prostate, 67(7):685-91 (2007)

Shigemura K., Sung SY., Kubo H., Arnold RS., Fujisawa M., Gotoh A., Zhau HE., and Chung LWK., "Reactive oxygen species mediate androgen receptor- and serum starvation-elicited downstream signaling of ADAM9 expression in human prostate cancer cells", Prostate, 67(7):722-31 (2007)

Shigemura K., Arbiser JL., Sun SY., Zayzafoon M., Johnstone PA., Fujisawa M., Gotoh A., Weksler B., Zhau HE., and Chung LWK., "Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells", Cancer, 109(7):1279-89 (2007)

Wu D., Zhau HE., Huang WC., Iqbal S., Habib FK., Sartor O., Cvitanovic L., Marshall FF., Xu Z., and Chung LWK., "cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis", Oncogene, 26(35):5070-7 (2007)

Gao X., Chung LWK, and Nie S., "Quantum dots for in vivo molecular and cellular imaging", Methods Mol Biol., 374:135-46 (2007)

Adam RM., Mukhopadhyay NK., Kim J., Di Vizio D., Cinar B., Solomon KR., and Freeman MR., "Cholesterol-sensitivity of endogenous and myristoylated Akt in prostate cancer cells", Cancer Res., 67:6238-46 (2007)

Xing Y., Chaudry Q., Shen C., Kong KY., Zhau HYE., Chung LW., Petros JA., O'Regan RM., Yezhelyev MV., Simons JW., Wang MD., and Nie S., "Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry", Nat Protocol., 2 (5):1152-65 (2007)

Spletter ML., Liu J., Liu J., Su H., Giniger E., Komiyama T., Quake S., and Luo L., "Lola regulates Drosophila olfactory projection neuron identity and targeting specificity", Neural Development, 2(14) (2007)

Xu Y., Fang F., Clair DK., Josson S., Sompol P., Spasojevic I., and Clair WH., "Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1{alpha},25-dihydroxyvitamin D3 in prostate cancer cells", Mol Cancer Ther, 6(7):2048-56. (2007)