Research and Clinical Trials
The Urology faculty at Cedars Sinai are involved in leading-edge clinical and laboratory research. The faculty members conduct research in tumor biology, cancer immunology, cancer prevention, health outcomes, new drugs and novel imaging. The research teams include physician scientists and basic science researchers who are highly funded by government agencies, including the National Institute of Health. These research studies provide a wealth of new ideas and concepts that are implemented into the care of our patients, when appropriate. The following is a brief list of some of our investigators and their ongoing projects.
- Neil Bhowmick, PhD
Dr. Bhowmick’s laboratory studies the role of the tumor microenvironment on cancer initiation, progression and metastasis to determine the risk of cancer progression and predict the benefits of therapeutic intervention.
- Leland W.K.Chung, PhD
Dr. Chung is the leader for the Urologic Oncology Research Program. His laboratory seeks to understand the "cross-talk" between the tumor and its microenvironment. They are working to develop new imaging strategies, drug targets, and biomarkers for cancers of the prostate, kidney, and bladder.
- Bekir Cinar, PhD
Dr. Cinar’s laboratory seeks to understand the signaling mechanisms and gene expressions relevant to cancer progression and metastasis
- Michael Freeman, PhD
Dr. Freeman’s research group studies cholesterol metabolism in prostate cancer, and the amoeboid phenotype in cancers that have the potential for spread to distant sites.
- Wen-Chin Huang, PhD
Dr. Huang’s laboratory studies the molecular basis of cancer growth and survival signaling.
- Hyung L. Kim, MD
Dr. Kim is the Director of Academic Programs in Urology. He treats patients with urologic cancers and conducts research in his laboratory. Dr. Kim’s laboratory evaluates strategies to stimulate the immune system to generate anticancer responses. The laboratory also seeks biomarkers that can help determine prognosis and treatment response.
Beatrice Knudsen, MD, PhD
Dr. Knudsen is the Director of Translational Pathology in the Department of Pathology and Laboratory Medicine. Her chief scientific interest is in cell communication and signaling with emphasis on the CMET pathway.
Cedars-Sinai has one of the largest state-of-the-art clinical research trial facilities of any private hospital in the nation. The 164,000-square foot clinical research trial facility is a testament to the Medical Center's commitment to remain on the forefront of applying research discovery to patient care. The Burns and Allen Research Institute provides a strong scientific, clinical and administration infrastructure to support these investigations. Core facilities funded by a National Institutes of Health grant provide specialized clinical research trial services in a cost-effective, efficient manner.
Cedars-Sinai Medical Center is fully accredited by the Association or the Accreditation of Human Research Protection Programs (AAHRPP) for all research involving the protection of patients. AAHRPP is a Washington, DC, based non-profit organization that uses voluntary, peer-driven, educational model to accredit institutions engaged in research involving human subjects.
Current clinical trials include:
- Title: Does Treatment of ADHD with Atomoxetine Help Urinary Symptoms?Summary: Does Treatment of ADHD with Atomoxetine Help Urinary Symptoms?
- Title: Comparison of Bacterial Populations in Girls With and Without Urinary Infection
Summary: Comparison of Bacterial Populations in Girls With and Without Urinary Infection
- Title: International Robot-Assisted Cystectomy Consortium
Summary: International Robot-assisted Cystectomy Consortium
- Title: A study to test the safety and effectiveness of pazopanib in patients who have undergone removal of kidney
Summary: GSK VEG113387: Pazopanib/Placebo for Adjuvant Renal Cell Carcinoma
- Title: Active Surveillance for Prostate Cancer
Summary: Active Surveillance of Prostate Cancer: A Repository of Human Specimens from Individuals with Low-Risk Prostate Cancer
- Title: Does bladder infusion with sterile saline after urinary incontinence surgery decrease time to discharge?
Summary: Does Bladder Instillation Reduce Time to Discharge After Sling Surgery
- Title: Does unrestricted activity following mid-urethral sling surgery impact continence outcomes and increase quality of life?
Summary: Impact of Unrestrictive Exercise Following Mid-Urethral Sling Surgery
- Title: A study of dietary intervention for patients on active surveillance for prostate cancer
Summary: Does altering diet help prevent progression of prostate cancer for patients on active surveillance
- Title: Study of everolimus to decrease the risk of recurrent kidney cancer after surgery
Summary: Does everolimus help prevent recurrence of kidney cancer after curative surgery (total nephrectomy or partial nephrectomy)
Click here to search Cedars-Sinai's database of ongoing clinical trials: