Keith Black, MD

Chair, Neurosurgery

Director, Maxine Dunitz Neurosurgical Institute
Email:keith.black@cshs.org
Phone:(310) 423-1773
Fax:(310) 423-1008

Institute Affiliation

Maxine Dunitz Neurosurgical Institute
Samuel Oschin Comprehensive Cancer Institute

Academic Appointments

Professor, Neurosurgery

Awards and Activities

Special Recognition National Academy of Science2000
NINDS-NIH Jacobs Javitz Award2000
Golden Plate Award - American Academy of Achievement1999
Ruth and Lawrence Harvey Chair in Neuroscience1997
Cover Time Magazine, "Heroes of Medicine"1997
Editorial Board: Frontiers in BioscienceCurrent
Listed: Americas Top Doctors and Best Doctors in AmericaCurrent
Editorial Board: Neurosurgery QuarterlyCurrent
Editorial Board: Gene Therapy and Molecular BiologyCurrent
Congress of Neurological Surgeons1982
American Association of Neurological Surgeons1991
Neurosurgical Society of America1993
American Academy of Neurological Surgery1995
Society of Neurological Surgeons2007

Research Focus

Biology of blood-brain barrier (BBB) and biochemical modulation of the blood-brain tumor barrier (BTB). Targeted drug delivery. Tumor immunology. Cancer vaccines. Cancer stem cells. Microwave tumor ablation..

Research Contributions

Developed method to selectively open BTB to increase drug delivery to brain tumor. Development of brain cancer vaccine. Identification of novel molecular targets to treat brain tumors..

Current investigations include:

Biology of BBB. Cancer vaccine and tumor immunology. Neuroregeneration. Cancer stem cells. Microwave tumor ablation. Nanotechnology for drug delivery.

Selected Publications

  1. Wheeler CJ, Das A, Liu G, Yu JS, Black KL: Clinical responsiveness of glioblastoma multiforme to chemotherapy after vaccination. Clin. Cancer Res., 10(16): 5316-26, 2004
  2. Wheeler CJ, Black KL: Dendritic cell vaccines and immunity in glioma patients. Front. Biosci., 10: 2861-81, 2005
  3. Yin D, Wang X, Konda BM, Ong JM, Hu J, Sacapano MR, Ko MK, Espinoza AJ, Irvin DK, Shu Y, Black KL: Increase in brain tumor permeability in glioma-bearing rats with nitric oxide donors. Clin. Cancer Res., 14(12): 4002-9, 2008
  4. Wheeler CJ, Black KL, Liu G, Mazer M, Zhang XX, Pepkowitz S, Goldfinger D, Ng H, Irvin D, Yu JS: Vaccination elicits correlated immune and clinical responses in glioblastoma multiforme patients. Cancer Res., 68(14): 5955-64, 2008
  5. Black KL, Yin D, Konda BM, Wang X, Hu J, Ko MK, Bayan JA, Sacapano MR, Espinoza AJ, Ong JM, Irvin D, Shu Y: Different effects of K(Ca) and K(ATP) agonists on brain tumor permeability between syngeneic and allogeneic rat models. Brain Res., , 2008
  6. Yuan X, Hu J, Belladonna ML, Black KL, Yu JS: Interleukin-23-expressing bone marrow-derived neural stem-like cells exhibit antitumor activity against intracranial glioma. Cancer Res., 66(5): 2630-8, 2006
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