Kent Taylor, PhD

Director, Molecular Genotyping Laboratory, Medical Genetics Institute
Email:kent.taylor@cshs.org
Phone:310-423-6695
Fax:(310) 423-0237

Academic Appointments

Professor, Pediatrics

Awards and Activities

Department of Veteran's Affairs: Performance Award1985
Reviewer: Inflammatory Bowel Disease2005 - 2008
American Society of Human Genetics2005 - 2008
American Gastroenterological Association2005 - 2008

Research Focus

Development of high throughput genotyping, data handling, principal components and pathway analysis, and gene annotation methods for genome wide association studies. Focus on identifying genes and pathways leading to inflammatory bowel disease in the Caucasian and Puerto Rican populations.

Research Contributions

Identified the population attributable risk of the IL23R gene to IBD and of the genes of the IL17-IL23 pathway as major contributors to disease. Demonstrated the "hygiene hypothesis" for IBD in Puerto Rico--that the lack of exposure to pathogens in childhood increases risk for IBD in this developing region.

Current investigations include:

Currently investigating the role of numerous pathways leading to sub-sets of inflammatory bowel disease.

Selected Publications

  1. Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, , Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, , , , Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ: Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet., , 2008
  2. Taylor KD, Targan SR, Mei L, Ippoliti AF, McGovern D, Mengesha E, King L, Rotter JI: IL23R haplotypes provide a large population attributable risk for Crohn's disease. Inflamm. Bowel Dis., , 2008
  3. Krauss RM, Mangravite LM, Smith JD, Medina MW, Wang D, Guo X, Rieder MJ, Simon JA, Hulley SB, Waters D, Saad M, Williams PT, Taylor KD, Yang H, Nickerson DA, Rotter JI: Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment. Circulation, 117(12): 1537-44, 2008
  4. Price AL, Weale ME, Patterson N, Myers SR, Need AC, Shianna KV, Ge D, Rotter JI, Torres E, Taylor KD, Goldstein DB, Reich D: Long-range LD can confound genome scans in admixed populations. Am. J. Hum. Genet., 83(1): 132-5; author reply 135-9, 2008
  5. Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, Rotter JI, Duerr RH, Cho JH, Daly MJ, Brant SR: Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat. Genet., 39(5): 596-604, 2007
  6. Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH: A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science, 314(5804): 1461-3, 2006
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