Maya Koronyo-Hamaoui, PhD

Research Scientist, Neurosurgery
Email:Maya.Koronyo@cshs.org
Phone:(310)423-7351
Fax:(310) 423-0302

Academic Appointments

Assistant Professor, Neurosurgery

Awards and Activities

ICAD 2008 "Hot topic" Selection2008
Joan and Jaime Constantiner and the ISPG Travel Awards2004
Tel Hashomer Excellent Research Presentation Awards2001
Faculty Magna Cum Laude Master's Degree1998
The Wolf Fund and Sackler School of Medicine Faculty Dean's Honor & Prize for Best Achievements1995
The Goerge S. Wise Life Sciences Faculty Dean's Honors & Prizes for Excellence1992
International Society of Psychiatric Genetics: member2000 - 2004
Society for Neuroscience: member2006
International Society to Advance Alzheimer Research and Treatment: member2007

Research Focus

Identifying and characterizing retinal pathologies specific to neurodegenerative disorders, especially Alzheimer's disease (AD). Investigating the underling immunological mechanism/s of repair in AD.

Research Contributions

Discovery of a link between genes in the glutamatergic system and genetic predisposition to complex psyciatric disorders. Development of immune-based therapies for AD. Identification of molecular and cellular mechanisms essencial for attenuating AD-like pathology. Contributed to identifying thymus immunodeficiency in amyotrophic lateral sclerosis. Identified a new way to diagnose AD-pathology through the retina.

Current investigations include:

Developing an immune-based therapy for AD. Studying the underlying immunological mechanisms involved in AD repair. Investigate pathologies specific to AD in the retina of human patients and rodent models.

Selected Publications

  1. Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, Kunis G, Pham M, Bakhsheshian J, Rogeri P, Black KL, Farkas DL, Schwartz M: Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9. J. Neurochem., , 2009
  2. Seksenyan A, Ron-Harel N, Azoulay D, Cahalon L, Cardon M, Rogeri P, Ko MK, Weil M, Bulvik S, Rechavi G, Amariglio N, Konen E, Koronyo-Hamaoui M, Somech R, Schwartz M: Thymic Involution in Amyotrophic Lateral Sclerosis. J. Cell. Mol. Med., , 2009
  3. Butovsky O, Kunis G, Koronyo-Hamaoui M, Schwartz M: Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. Eur. J. Neurosci., 26(2): 413-6, 2007
  4. Butovsky O, Koronyo-Hamaoui M, Kunis G, Ophir E, Landa G, Cohen H, Schwartz M: Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc. Natl. Acad. Sci. U.S.A., 103(31): 11784-9, 2006
  5. Koronyo-Hamaoui M, Frisch A, Stein D, Denziger Y, Leor S, Michaelovsky E, Laufer N, Carel C, Fennig S, Mimouni M, Ram A, Zubery E, Jeczmien P, Apter A, Weizman A, Gak E: Dual contribution of NR2B subunit of NMDA receptor and SK3 Ca(2+)-activated K+ channel to genetic predisposition to anorexia nervosa. Journal of psychiatric research, 41(1-2): 160-7, 2005
  6. Koronyo-Hamaoui M, Danziger Y, Frisch A, Stein D, Leor S, Laufer N, Carel C, Fennig S, Minoumi M, Apter A, Goldman B, Barkai G, Weizman A, Gak E: Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study. Mol. Psychiatry, 7(1): 82-5, 2002
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