Michael Lewis, MD

Medical Director, Respiratory Intensive Care Unit
Email:michael.lewis@cshs.org
Phone:(310) 423-1832
Fax:(310) 423-0129

Academic Appointments

Professor, Medicine

Awards and Activities

Editorial Board, Journal of Applied Physiology1996
Editorial Board: Open Journal of PhysiologyCurrent
American Lung Association of CA, Member Research Fellowship training Grant Review Committee1992 - 1997
American Thoracic Society, Respiratory Structure and Function Committee, Member1992
American Lung Association of CA; Chairman Research Fellowship Training Grant Review Committee1997 - 1998

Research Focus

Basic research in respiratory muscle physiology and cell biology with specific emphasis on the effects of emphysema on diaphragm structure and function, undernutrition on respiratory muscles, hormonal and pharmacologic influences on respiratory muscles, diaphragm development and mechanisms responsible for these influences. Major interest in biochemical mechanisms underlying disordered muscle protein turnover and muscle fiber atrophy in cachectic states.

Research Contributions

Described the effect of emphysema on the functional and morphometric properties of the diaphragm. Described in a variety of models biochemical muscle dertminants of the actions of anabolic steroids on skeletal muscle. Described signaling pathways of importance in disordered protein turnover in cachectic states.

Current investigations include:

Biochemical and molecular mechanisms responsible for respiratory and limb muscle fiber atrophy in states of acute undernutrition. Signaling of synthetic and proteolytic pathways in muscle ; transgenic and knockout models, muscle cell cultures; genetic and pharmacologic manipulation of signaling pathways; gene electroporation

Selected Publications

  1. Lewis MI, Fournier M, Storer TW, Bhasin S, Porszasz J, Ren SG, Da X, Casaburi R: Skeletal muscle adaptations to testosterone and resistance training in men with COPD. J. Appl. Physiol., 103(4): 1299-310, 2007
  2. Lewis MI, Bodine SC, Kamangar N, Xu X, Da X, Fournier M: Effect of severe short-term malnutrition on diaphragm muscle signal transduction pathways influencing protein turnover. J. Appl. Physiol., 100(6): 1799-806, 2006
  3. Lewis MI, Fournier M, Da X, Li H, Mosenifar Z, McKenna RJ, Cohen AH: Short-term influences of lung volume reduction surgery on the diaphragm in emphysematous hamsters. Am. J. Respir. Crit. Care Med., 170(7): 753-9, 2004
  4. Fournier M, Huang ZS, Li H, Da X, Cercek B, Lewis MI: Insulin-like growth factor I prevents corticosteroid-induced diaphragm muscle atrophy in emphysematous hamsters. Am. J. Physiol. Regul. Integr. Comp. Physiol., 285(1): R34-43, 2003
  5. Lewis MI, Horvitz GD, Clemmons DR, Fournier M: Role of IGF-I and IGF-binding proteins within diaphragm muscle in modulating the effects of nandrolone. Am. J. Physiol. Endocrinol. Metab., 282(2): E483-90, 2002
  6. Lewis MI, Zhan WZ, Sieck GC: Adaptations of the diaphragm in emphysema. J. Appl. Physiol., 72(3): 934-43, 1992
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