Wagner LabThe research objective of the laboratory is to employ new advancements in magnetic resonance technology to examine how we can use metabolomics to examine cancer and other diseases. Our lab focuses on developing technology to enhance the magnetic resonance signal thereby reducing the required examine time to the point of real-time acquisition of metabolism. The goal is develop a magnetic resonance imaging and spectroscopy hyperpolarization program that spans from basic cell metabolism to in vivo animal studies to human clinical applications. Current research activities are concentrated on developing biomarkers for breast and prostate research which utilizes parahydrogen induced polarization (PHIP) as the form of hyperpolarization. We have just completed development of new instrumentation and software for producing these hyperpolarized biomarkers in less than one minute.
Hyperpolarization process carried out in less than one minute utilizing PHIP equipment for producing a choline analog that can be detected with high sensitivity using magnetic resonance spectroscopy/imaging.