Sandra Orsulic, PhD
Director, Women's Cancer Biology
|Samuel Oschin Comprehensive Cancer Institute|
|Women's Cancer Research Institute|
|Associate Professor, OBGYN|
To understand the genetic and epigenetic changes leading to the initiation and metastatic spread of ovarian cancer; generate suitable pre-clinical models for testing therapies that target specific biochemical pathways; and identify recognizable histological or molecular markers that could be used for early cancer detection.
Developed a genetically defined mouse model of ovarian epithelial cancer that recapitulates human ovarian carcinoma development and progression. The laboratory used this model to study oncogene cooperation, molecular mechanisms of tumor sensitivity and resistance to pathway-targeted therapy, immune responses in cancer progression, and Brca1-related ovarian tumorigenesis.
Current investigations include:
Development of mouse models of ovarian cancer; molecular characterization of cooperating biochemical pathways in ovarian cancer initiation; and identification and functional characterization of key genes that promote ovarian cancer progression and metastasis.
- Miao J, Wang Z, Provencher H, Muir B, Dahiya S, Carney E, Leong CO, Sgroi DC, Orsulic S: HOXB13 promotes ovarian cancer progression. Proc. Natl. Acad. Sci. U.S.A., 104(43): 17093-8, 2007
- Xing D, Orsulic S: A mouse model for the molecular characterization of brca1-associated ovarian carcinoma. Cancer Res., 66(18): 8949-53, 2006
- Gasser S, Orsulic S, Brown EJ, Raulet DH: The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature, 436(7054): 1186-90, 2005
- Xing D, Orsulic S: A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance. Proc. Natl. Acad. Sci. U.S.A., 102(19): 6936-41, 2005
- Xing D, Orsulic S: Modeling resistance to pathway-targeted therapy in ovarian cancer. Cell Cycle, 4(8): 1004-6, 2005
- Orsulic S, Li Y, Soslow RA, Vitale-Cross LA, Gutkind JS, Varmus HE: Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell, 1(1): 53-62, 2002