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The Cedars-Sinai Diabetes & Obesity Research Institute's goals are to examine ways to predict, prevent, treat and cure diabetes, obesity and associated conditions. It is now well accepted that diabetes is one of the most rapidly expanding chronic ailments in the United States and in many countries around the world. The investigators and staff, under the leadership of Richard Bergman, PhD, have amassed an outstanding list of accomplishments in understanding the pathogenesis of this disease. The research team's accomplishments include the development of the Minimal Model Approach for assessment of metabolic status, and the Disposition Index, the most powerful predictor of the onset of type two diabetes. Other areas of research include the mechanisms of insulin resistance, the consequences of abdominal obesity, the metabolic effects of psychotropic medications and the use of mathematical modeling techniques to corroborate genetic loci, which contribute to the risk of developing diabetes. Current research initiatives include examining the relationship between sleep patterns and diabetes and understanding the mechanisms by which bariatric surgery reduces or even eliminates the diabetic condition.
The institute's world-class team is focused on cutting-edge translational research with the intent of confronting and mitigating one of the most problematic diseases in the U.S.