Dolores Di Vizio, MD, PhD

Research Scientist, Surgery

Email:Dolores.Divizio@cshs.org
Phone:(310) 423-7709
Fax:(310) 967-3809

Academic Appointments

Associate Professor, Surgery
Associate Professor, Biomedical Sciences
Associate Professor, Pathology and Lab Medicine

Awards and Activities

Award for exceptional research2013
The Howard Temin Award from the NCI2008
Federico II/AECOM2000 - 2002
several top journalsCurrent
New York Academy of Sciences2005 - 2007
American Association for Cancer Research (AACR)2011
Society for Basic Urologic Research (SBUR)2011

Research Focus

Mechanism of metastasis of prostate cancer. Employ molecular, cellular, animal and human tissue models to perform molecular and functional analysis of circulating Large Oncosome in prostate cancer and other tumors. Molecular profiling is based on large scale quantitative LC/LC-MS/MS, and NGS.

The functional role of Caveolin-1 in cancer associated fibroblasts

Research Contributions

Leader in the discovery of of the functional role of epithelial and stromal caveolin-1 in prostate cancer
Leader in the discovery of large oncosomes, atypically large tumor-derived extracellular vesicles that contain molecules functionally to cancer progression, which can be detected in the ciruclation.

Current investigations include:

Mechanism of prostate cancer metastasis
Large Oncosomes as Biomarkers of tumor progression
Molecular and functional analysis of circulating Large Oncosome in prostate cancer and other tumors
Functional characterization of the miRNA cargo of Large Oncosomes in human tumors
The functional role of Caveolin-1 in cancer associated fibroblasts

Selected Publications

  1. Tu DD, Chung YG, Gil ES, Seth A, Franck D, Cristofaro V, Sullivan MP, Di Vizio D, Gomez 3rd, Adam RM, Kaplan DL, Estrada Jr, Mauney JR: Bladder tissue regeneration using acellular bi-layer silk scaffolds in a large animal model of augmentation cystoplasty. Biomaterials, 34(34): 8681-9, 2013
  2. Mukhopadhyay NK, Kim J, You S, Morello M, Hager MH, Huang WC, Ramachandran A, Yang J, Cinar B, Rubin MA, Adam RM, Oesterreich S, Di Vizio D, Freeman MR: Scaffold attachment factor B1 regulates the androgen receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2. Oncogene, , 2013
  3. Majumdar S, Gong EM, Di Vizio D, Dreyfuss J, Degraff DJ, Hager MH, Park PJ, Bellmunt J, Matusik RJ, Rosenberg JE, Adam RM: Loss of Sh3gl2/endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior. Neoplasia, 15(7): 749-60, 2013
  4. Seth A, Chung YG, Kim D, Ramachandran A, Cristofaro V, Gomez 3rd, Tu D, Huang L, Benowitz LI, Di Vizio D, Sullivan MP, Adam RM: The impact of discrete modes of spinal cord injury on bladder muscle contractility. BMC Urol, 13: 24, 2013
  5. Seth A, Chung YG, Gil ES, Tu D, Franck D, Di Vizio D, Adam RM, Kaplan DL, Estrada Jr, Mauney JR: The performance of silk scaffolds in a rat model of augmentation cystoplasty. Biomaterials, 34(20): 4758-65, 2013
  6. Kim J, Di Vizio D, Kim TK, Kim J, Kim M, Pelton K, Clinton SK, Hai T, Hwang D, Solomon KR, Freeman MR: The response of the prostate to circulating cholesterol: activating transcription factor 3 (ATF3) as a prominent node in a cholesterol-sensing network. PLoS ONE, 7(7): e39448, 2012

Lab Information

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