Gislâine A. Martins, PhD

Research Scientist, Inflammatory Bowel & Immunobiology Research Institute

Email:martinsg@cshs.org
Phone:(310) 423-0278
Fax:(310) 423-0224

Academic Appointments

Assistant Professor, Medicine

Awards and Activities

Invitrogen Trainee Achievement Award American Association of Immunologists2008
Welcome Trust Scholarship2000
Young Investigator Award Braz Soc Biochem & Mol Biol2000
Brazilian Society of Immunology1996
American Association of Immunologists2006
Society for Mucosal Immunology2009

Research Focus

Molecular regulation of immune responses, with a major focus on transcriptional regulation of T lymphocyte terminal effector differentiation and its implication in inflammatory diseases.

Research Contributions

Identified new pathways regulating effector T cell function, including the role of transcriptional repressor Blimp-1 in modulating several aspects of T cell responses.
Contributed to the identification of the transcriptional factor Eomesodermin in controlling CD8+ T cell function.
Made key contributions to the the understanding of the mechanisms regulating immune response to infection.

Current investigations include:

Currently using several genetically manipulated mice models, human immune cells, and cellular and molecular approaches to investigate the genetic pathways controlled by the transcriptional repressor Blimp-1 in T cells, as a model to identify new molecular networks responsible for the control of T cell responses in dynamic environments such as mucosal interfaces.

Selected Publications

  1. Salehi S, Bankoti R, Benevides L, Willen J, Couse M, Silva JS, Dhall D, Meffre E, Targan S, Martins GA: B Lymphocyte-Induced Maturation Protein-1 Contributes to Intestinal Mucosa Homeostasis by Limiting the Number of IL-17-Producing CD4+ T Cells. J. Immunol., 189(12): 5682-93, 2012
  2. Rutishauser RL, Martins GA, Kalachikov S, Chandele A, Parish IA, Meffre E, Jacob J, Calame K, Kaech SM: Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity, 31(2): 296-308, 2009
  3. Martins GA, Cimmino L, Liao J, Magnusdottir E, Calame K: Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival. J. Exp. Med., 205(9): 1959-65, 2008
  4. Martins G, Calame K: Regulation and functions of Blimp-1 in T and B lymphocytes. Annu. Rev. Immunol., 26: 133-69, 2008
  5. Martins GA, Cimmino L, Shapiro-Shelef M, Szabolcs M, Herron A, Magnusdottir E, Calame K: Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. Nat. Immunol., 7(5): 457-65, 2006
  6. Martins GA, Hutchins AS, Reiner SL: Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression. J. Immunol., 175(9): 5981-5, 2005

Lab Information