Robert Baloh, MD, PhD

Director, Neuromuscular Medicine, Neurology

Institute Affiliation

Regenerative Medicine Institute

Academic Appointments

Associate Professor, Neurology

Awards and Activities

Essey Committment to a Cure Award2012
Member of the American Neurologic Association2011
Washington University Distinguished Investigator Award2011
S. Weir Mitchell Award, American Academy of Neurology2007
Elsevier Prize - World Muscle Society2006
Chief Resident in Neurology2004 - 2005
David M. Kipnis Award, Washington University2000
Ann W. and Spencer T. Olin Medical Scientist Fellowship1999
Proceedings of the National Academy of SciencesCurrent
Journal of Clinical InvestigationCurrent
Science Translational MedicineCurrent
Human Molecular GeneticsCurrent
Nature MedicineCurrent
EMBO JournalCurrent
Journal of NeurologyCurrent
PLoS GeneticsCurrent
Nature ProtocolsCurrent
Journal of NeurochemistryCurrent
Brain ResearchCurrent
Genes Brain and BehaviorCurrent
Experimental NeurologyCurrent
Archives of NeurologyCurrent
Acta NeuropathologicaCurrent
Annals of NeurologyCurrent
Journal of NeuroscienceCurrent
Neuromuscular DisordersCurrent
American Academy of Neurology2002
Peripheral Nerve Society2006
Society for Neuroscience2006
American Neurologic Association2011

Research Focus

To understand molecular mechanisms of neuromuscular diseases using in vitro and animal modeling, based on insights from human genetics. Focus areas include amyotrophic lateral sclerosis (ALS) and inherited neuropathy. We employ induced pluripotent stem cells models and rodent models to understand the biology of these diseases and as a platform to test new treatment strategies.

Research Contributions

Developed animal and cellular models of ALS that are used by researchers worldwide for therapeutics development, and discovered multiple new inherited neuromuscular disorders.

Current investigations include:

Transgenic animal models and iPSC-models of neurodegenerative diseases including ALS and inherited neuropathies. Therapeutics development for ALS and inherited neuropathies.

Selected Publications

  1. Cady J, Allred P, Bali T, Pestronk A, Goate A, Miller TM, Mitra RD, Ravits J, Harms MB, Baloh RH: Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes. Ann. Neurol., 77(1): 100-13, 2014
  2. Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, Rigo F, Bennett CF, Otis TS, Svendsen CN, Baloh RH: Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci Transl Med, 5(208): 208ra149, 2013
  3. Udan-Johns M, Bengoechea R, Bell S, Shao J, Diamond MI, True HL, Weihl CC, Baloh RH: Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones. Hum. Mol. Genet., 23(1): 157-70, 2013
  4. Harms MB, Cady J, Zaidman C, Cooper P, Bali T, Allred P, Cruchaga C, Baughn M, Libby RT, Pestronk A, Goate A, Ravits J, Baloh RH: Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis. Neurobiol. Aging, 34(9): 2234.e13-9, 2013
  5. Misko AL, Sasaki Y, Tuck E, Milbrandt J, Baloh RH: Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration. J. Neurosci., 32(12): 4145-55, 2012
  6. Harms MB, Sommerville RB, Allred P, Bell S, Ma D, Cooper P, Lopate G, Pestronk A, Weihl CC, Baloh RH: Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy. Ann. Neurol., 71(3): 407-16, 2012

Lab Information

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