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Shawn Wagner, PhD
Technical Director, Small Animal MRI, Biomedical Imaging Research Institute, Biomedical Sciences
|Assistant Professor, Biomedical Sciences|
Awards and Activities
|Member, Int'l Society of Magnetic Resonance in Medicine||2007|
|Safety Committee, International Society of Magnetic Resonance in Medicine (ISMRM)||2011|
|Member, American Association of Cancer Research||2011|
Hyperpolarization is a new and emerging field within magnetic resonance imaging providing enhancement of signal over 10,000 times what is currently available. Our current research utilizes a method of polarization using parahydrogen to transfer the polarization from the hydrogen nuclei to a carbon or nitrogen nucleus with a slower signal decay allowing for in vivo studies, focusing on prostate and breast cancer.
Defined the pH dependence of hyperpolarizing succinate delivery to tumors and the pH contribution to the chemical shift. Developed the concepts for hyperpolarized spin accounting, a requirement for understanding downstream metabolism.
Current investigations include:
Prostate and breast cancer metabolic research; 15N Choline hyperpolarization; Parahydrogen Induced Polarization Equipment construction and modification; PHIP Biomarkers development and hydrogenation chemical rate catalyst dependency.
- Ross BD, Bhattacharya P, Wagner S, Tran T, Sailasuta N: Hyperpolarized MR imaging: neurologic applications of hyperpolarized metabolism. AJNR. American journal of neuroradiology, 31(1): 24-33, 2009
- Bhattacharya P, Chekmenev EY, Reynolds WF, Wagner S, Zacharias N, Chan HR, BÃ¼nger R, Ross BD: Parahydrogen-induced polarization (PHIP) hyperpolarized MR receptor imaging in vivo: a pilot study of 13C imaging of atheroma in mice. NMR Biomed, 24(8): 1023-8, 2011