Tyler Pierson, MD, PhD

Staff Physician, PD Neurology

Phone:(310) 423-4441
Fax:(310) 248-8066

Institute Affiliation

Regenerative Medicine Institute

Academic Appointments

Clinical Instructor, Pediatrics

Awards and Activities

Fashion Industries Guild Endowed Fellowship in Pediatric Neuromuscular Diseases2012
Team Science Award from the Society for Clinical and Translational Science (SCTS)2011
National Human Genome Research Institute Merit Award2011
Child Neurology Society2006
American Society of Gene and Cell Therapy2008
American Academy of Neurology2008
American Neurological Association2014

Research Focus

Identification and diagnosis of rare pediatric neurogenetic disorders in the clinic and the laboratory with genomics and stem-cell biology. Further investigations regarding the modeling and treatment of rare pediatric neurogenetic disorders in the laboratory. Implementation of gene and stem-cell based therapies for rare neurogenetic disorders.

Research Contributions

Expert in clinical and research application of genomics and rare neurological disorders

Current investigations include:

Development of inducible gene regulation system for use in the central nervous system. Investigations of molecular and cellular etiologies of SPG11 with induced pluripotent stem cells. In vitro modeling of rare neurogenetic disorders with induced pluripotent stem cells.

Selected Publications

  1. Pizzino A, Pierson TM, Guo Y, Helman G, Fortini S, Guerrero K, Saitta S, Murphy JL, Padiath Q, Xie Y, Hakonarson H, Xu X, Funari T, Fox M, Taft RJ, van der Knaap MS, Bernard G, Schiffmann R, Simons C, Vanderver A: TUBB4A de novo mutations cause isolated hypomyelination. Neurology, 83(10): 898-902, 2014
  2. Renvoisé B, Chang J, Singh R, Yonekawa S, FitzGibbon EJ, Mankodi A, Vanderver A, Schindler A, Toro C, Gahl WA, Mahuran DJ, Blackstone C, Pierson TM: Lysosomal abnormalities in hereditary spastic paraplegia types SPG15 and SPG11. Ann Clin Transl Neurol, 1(6): 379-389, 2014
  3. Pierson TM, Yuan H, Marsh ED, Fuentes-Fajardo K, Adams DR, Markello T, Golas G, Simeonov DR, Holloman C, Tankovic A, Karamchandani MM, Schreiber JM, Mullikin JC, PhD for the NISC Comparative Sequencing Program, Tifft CJ, Toro C, Boerkoel CF, Traynelis SF, Gahl WA: GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine. Ann Clin Transl Neurol, 1(3): 190-198, 2014
  4. Yuan H, Hansen KB, Zhang J, Pierson TM, Markello TC, Fajardo KV, Holloman CM, Golas G, Adams DR, Boerkoel CF, Gahl WA, Traynelis SF: Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy. Nat Commun, 5: 3251, 2014
  5. Zhu PP, Denton KR, Pierson TM, Li XJ, Blackstone C: Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A. Hum. Mol. Genet., 23(21): 5638-48, 2014
  6. Pierson TM, Markello T, Accardi J, Wolfe L, Adams D, Sincan M, Tarazi NM, Fajardo KF, Cherukuri PF, Bajraktari I, Meilleur KG, Donkervoort S, Jain M, Hu Y, Lehky TJ, Cruz P, Mullikin JC, Bonnemann C, Gahl WA, Boerkoel CF, Tifft CJ: Novel SNP array analysis and exome sequencing detect a homozygous exon 7 deletion of MEGF10 causing early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD). Neuromuscul. Disord., 23(6): 483-8, 2013

Lab Information

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