Instrumentation

Multiple biomedical imaging systems are available at the Imaging Core. We provide experienced technologists for the acquisition and basic image processing, as well as for administration of anesthesia (small animals), contrast agents and PET tracers. Please refer to iLab for our imaging rates.

Siemens MAGNETOM® Verio 3T MRI
Technical Director: zhaoyang.fan@csmc.edu

  • Human and large animal imaging
  • Superb image quality and fast acquisition
  • Advanced software packages for brain function, angiography, cardiac function, body motion and multimodality image fusion
  • Functional MRI task presentation system
  • Proton and multinuclear spectroscopy: single voxel, 2D and 3D with analysis
  • Diffusion imaging: ADC mapping, fibre tracking
  • Angiography: noncontrast or contrast-enhanced
  • Vessel wall imaging: plaque size and composition characterization
  • T1/T2 mapping
  • Cardiac imaging: perfusion, diffusion, function, late-enhancement
  • Body imaging: cancer, radiotherapy planning, spine
  • Molecular imaging: cell tracking, targeted enhancement


Siemens Biograph mMR MR-PET

Technical Directors: damini.dey@csmc.edu and rohan.dharmakumar@cshs.org

  • Human and large animal imaging
  • True simultaneous MR and PET whole body acquisition resulting in improved co-registration of PET and MRI images, shorter overall imaging times and ability to observe rapidly changing physiological processes simultaneously
  • Available for research and clinical (standard-of-care) use
  • 3T MRI similar to Verio system (see above)
  • Functional MRI task presentation system
  • Multinuclear MR spectroscopy available


Bruker BioSpin 9.4T micro-MRI
Technical Director: shawn.wagner@csmc.edu

  • Small animal imaging
  • 1H, 15N, 13C and X nuclei imaging and spectroscopy for in vivo and molecular MRI applications
  • Proton spectroscopy, single voxel, 2D and 3D capabilities
  • Metabolic composition and fat analysis
  • Diffusion imaging with fiber tracking capability
  • Angiography
  • Relaxation time measurements and analysis (T1 and T2)
  • Stroke detection, e.g., cerebral blood flow, diffusion tensor imaging
  • Cardiac imaging and function measurement
  • Tumor imaging
  • Longitudinal size analysis


TriFoil Triumph II micro-PET/SPECT/CT
Technical Directors: wafa.tawackoli@csmc.edu and yifang.zhou@csmc.edu

  • Small animal imaging
  • Fully integrated trimodality molecular imaging system
  • Optimal applications: oncology, cardiology, neurology, toxicology and cell therapy
  • 3D molecular imaging
  • Longitudinal analysis
  • Single-axis animal bed track facilitates automated co- registration between modalities
  • Tumor imaging
  • Molecular cardiac function and coronary heart disease
  • Stem cell tracking and analysis
  • Neurobiology and functional brain Imaging


Scanco vivaCT40 micro-CT
Technical Director: wafa.tawackoli@csmc.edu

  • Small animal in vivo and specimens
  • Outstanding high resolution CT (10 µm)
  • Respiratory gating
  • 3D morphology of cartilage and bone
  • Analysis of visceral and subcutaneous adiposity
  • Imaging of tissue engineering scaffold
  • Hierarchical micro imaging for multi-scale analysis of large vascular networks
  • 3D evaluation of the trabecular and cortical structure
  • Bone volume measurement
  • Quantitative imaging of lung tumors


IVIS® Spectrum Optical Imaging System
Technical Director: wafa.tawackoli@csmc.edu

  • Whole-body in vivo for small animals
  • High resolution fluorescence and bioluminescence
  • Multiple labels
  • Relative quantitative analysis
  • Full spectral tunability
  • Epi-illumination
  • Trans-illumination
  • Longitudinal analysis and quantification
  • Absolute calibration
  • Multimodal co-registration (PET, CT, MRI)
  • Spectral unmixing
  • Optimal applications: Oncology imaging, stem cell tracking and analysis, drug delivery, cardiovascular diseases, angiogenesis, infection disease, inflammation, pulmonary


IVIS® Lumina XR Optical Imaging System
Technical Director: wafa.tawackoli@csmc.edu

  • Whole-body in vivo for small animals
  • High resolution fluorescence and bioluminescence with precise x-ray overlay option
  • Multiple labels
  • Relative quantitative analysis
  • Full spectral tunability
  • Epi-illumination
  • Trans-illumination
  • Longitudinal analysis and quantification
  • Absolute calibration
  • Multimodal co-registration (PET, CT, MRI)
  • Spectral unmixing
  • Optimal applications: Oncology imaging, stem cell tracking and analysis, drug delivery, cardiovascular diseases, angiogenesis, infection disease, inflammation, pulmonary


CRi Maestro Fluorescence
Technical Director: wafa.tawackoli@csmc.edu

  • High resolution fluorescence
  • Multiple labels
  • Relative quantitative analysis
  • Applications: Fluorescent tumor models, antibody based assays, molecular targeting agents, fluorescent drug pharmacokinetics, angiogenesis markers






Nikon Eclipse Ti Microscope
Technical Director: wafa.tawackoli@csmc.edu

  • Inverted microscope system
  • Applications: molecular pathology, neurobiology, target identification, regenerative studies, veterinary, cell culture, developmental biology, embryology/IVF, cell signaling

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