Shuang Chen, MD, PhD
Assistant Professor, Principal Investigator
Chen received her doctorate at Hebei Medical University China in Cardiovascular Physiology. After post-doctoral studies at Harbor-UCLA investigating the nitric oxide and GABA signal transduction in the somatosympathetic reflexes and their cardiovascular control mechanisms, Chen joined the lab of Moshe Arditi, MD, studying varying aspects of innate immunity, Chlamydia pneumoniae infection, and atherosclerosis. Chen has received an AHA Grant-in-Aid Award and has recently been awarded her first R01 from the NIH to investigate the role of IL-17 and the NLRP3 inflammasome activation in atherogenesis.
Timothy R. Crother, PhD
Crother received his doctorate at Indiana University in Molecular, Cellular, and Developmental Biology. After post-doctoral studies at UCLA investigating the pathogenesis of Borrelia burgdorferi (the causative agent of Lyme disease), Crother joined the lab of Moshe Arditi, MD, studying varying aspects of innate immunity, Chlamydia pneumoniae infection and asthma.
Kenichi Shimada, PhD
Shimada received his PhD in Microbiology and Immunology at Kitasato University. Shimada joined the Arditi Laboratory and is now studying host defenses against pathogens, innate immunity, and immune regulation. Shimada made the seminal observation that oxidized mitochondrial DNA during apoptosis is released and binds to cytosolic NLRP3 to activate it for IL-1 beta production (immunity paper). Shimada is now investigating the mitochondria and NLRP3 inflammasome activation mechanisms, acute lung injury and the role of Rip2 and Th17 in Chlamydia pneumoniae infections.
Shervin Rabizadeh, MD
Attending Physician, Pediatric Gastroenterology
Rabizadeh received his bachelor's degree from the University of California, Los Angeles and his medical degree from Tufts University School of Medicine. He completed his pediatric residency, pediatric chief residency, and pediatric gastroenterology fellowship at Johns Hopkins University School of Medicine before coming to Cedars-Sinai. He is studying the relationship of bacteria, immunology and inflammation as it pertains to diseases like inflammatory bowel disease. Rabizadeh has a KO8 award (Arditi—mentor).
Heather Jones, MD
Attending Physician, Pulmonary and Critical Care
Jones received her medical degree from the Medical College of Pennsylvania/Hahnemann University and completed her residency in Internal Medicine at Boston Medical Center. After residency, she trained in pulmonary and critical care at Johns Hopkins Hospital and completed her research fellowship training at the National Heart, Lung, and Blood Institute of the National Institutes of Health. She is a faculty member in the Division of Pulmonary and Critical Care Medicine and the Medical Director of a Medical-Surgical Intensive Care Unit at Cedars-Sinai. Jones is interested in the immunological mechanisms responsible for the development of ventilator-induced acute lung injury and in potential therapeutic agents to modulate this disease, and conducts her research in the Arditi Laboratory
Norika Chiba, PhD
Chiba received her doctorate at Nagoya University Graduate School of Medicine in Integrated Molecular Medicine. She investigated TLR-signaling in mast cells and studied the molecular biology of bone at Kagoshima University Graduate School of Medical and Dental Sciences. She is currently investigating the role of mast cells in innate immunity, Chlamydia pneumoniae infection, and atherosclerosis enhanced by C. pneumoniae infection in the Arditi Laboratory.
Young Ho Lee, PhD
Lee received his doctoral degree in immunology studying autoimmune disorders at Nagoya University of Medicine. Lee joined Arditi’s Laboratory in 2009 and is currently studying the mechanism of Kawasaki disease pathogenesis using a mouse model of the disease. He published the role of IL-1beta in the generation of the KD vasculitis and has received an AHA Post-doctoral Award.
Jargalsaikahn Dagvadorj, PhD
Dagvadorj received his doctorate at Aichi Medical University, Japan, where he studied the regulatory role of IL-10 on Toll-like receptor (TLR) signaling pathways. He joined Arditi Laboratory and is currently studying bacterial agent-induced activation of the innate immune system and TLR signaling. He has generated the MyD88-Tie2 cre-floxed mice and is investigating the role of vascular EC MYD88 in LPS-induced acute lung injury in the Arditi lab.
Gantsetseg Tumurkhuu, PhD
Tumurkhuu received her doctorate in Immunology in 2008 from Aichi Medical University, Japan. Her research was focused on the function, signal transduction pathways and regulation of Toll-like Receptors (TLR), especially LPS-mediated activation of innate immunity and septic shock. Her current studies involve the molecular pathogenesis of infection and immunity in atherosclerotic development.
Daiko Wakita, PhD
Wakita received his PhD from Hokkaido University investigating the regulatory mechanisms of tumor-inhibiting and tumor-promoting immune responses during cancer development. He is an accomplished tumor immunologist. Since joining Arditi Laboratory, he is investigating the molecular mechanisms involved in the development of vasculitis in the Kawasaki disease mouse model. He is also investigating the innate immune mechanism and vascular signaling during lung cancer metastasis.