Innate Immunity and Host Pathogen Interaction Laboratory
The Arditi Laboratory is led by Moshe Arditi, MD, Director of the Infectious and Immunological Diseases Research Center (IIDRC) and the Division of Pediatric Infectious Diseases. The laboratory investigates innate immunity and host-pathogen interactions as they relate to acute and chronic inflammatory diseases, with particular focus on the lung and the cardiovascular systems. The disease models that we focus on include molecular pathogenesis of bacterial infections of the lungs and the role of innate and adaptive immunities in various infections and infection-induced acute and chronic inflammatory diseases, such as allergic asthma and chronic lung changes. Another major focus is the role of innate and adaptive immunity in high-fat diet- and infection-induced atherosclerosis in various hypercholesterolemic mouse models; of particular interest is chronic Chlamydia pneumoniae infection-induced allergic sensitization for asthma as well as acceleration of atherosclerosis. The laboratory is also known for expertise on models of immune-mediated coronary arteritis, such as Kawasaki disease mouse models, and the role of innate and adaptive immunity in Kawasaki disease-induced coronary arteritis. We are also investigating the basic mechanism of NLRP3 inflammasome activation, mitochondrial oxidative DNA damage and apoptosis as they relate to IL-1 beta production. There is a strong focus on the role of IL-1 alpha and beta in various inflammatory diseases and novel ways to treat various inflammatory diseases.