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Click here for a complete list of Bekir Cinar, PhD publications.
Selected Key Publications
Cinar B, De Benedetti A, Freeman MR. Post-translational regulation of the androgen receptor by the mammalian target of rapamycin. Cancer Res. 2005;65:2547-53.
Adam RM, Mukhopadhyay NK, Kim J, Di Vizio D, Cinar B, Solomon KR, Freeman MR. Cholesterol-sensitivity of endogenous and myristoylatedAkt in prostate cancer cells. Cancer Res.2007;67:6238-46.
Cinar B, Mukhopadhyay NK, Meng G, Freeman, MR. Phosphoinositide 3-kinase-independent nongenomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. J Biol Chem. 2007;282:29584-593.
Cinar B, Fang PK, Luchtman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.The EMBO J.2007;26:4523-34.
Cinar B, Kisaayak-Collak F, Lopez D, Akgul S, Gioeli DG, Mukhopadhyay NK, Murat Kilicarslan, Freeman MR. MST1 is a multifunctional and caspase-independent inhibitor of androgenic Signaling. Cancer Res.2011;71:4303-4313.
Soifer H, Souleimanian, N, Wang S, Voskresenskiy A, Kisaayak-Collak, F, Cinar B, Stein CA. Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells. J Biol Chem.2012;287:3777-87.
Kisaayak Collak F, Yagiz K, Luthringer DJ, Erkaya B, Cinar B. Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-Like kinase 1. J Biol Chem. 2012;287:23698-709.