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Areas of research include investigating genetic factors in polycystic ovary syndrome, particularly genes involved in adrenal androgen excess and response to metformin therapy; investigating the role of energy-related and diabetes-related genes in insulin clearance; and searching for genetic factors affecting the insulin system and subclinical atherosclerosis in Hispanic and other populations. In addition, research is ongoing in the phenotyping of insulin resistance by physiologic infusion studies, and in a pharmacogenetic study of the metabolic effects of statin therapy. We are also participating in large-scale consortia for elucidation of genes regulating insulin clearance, insulin resistance and diabetes.
We were the first to report that processes whereby insulin is removed from the circulation are highly determined by genetic factors.