Click here for a complete list of Ramachandran Murali, PhD publications.

Selected Key Publications

Murali R, Sharkey DJ, Daiss JL, Murthy HM. Crystal structure of Taq DNA polymerase in complex with an inhibitory Fab: the Fab is directed against an intermediate in the helix-coil dynamics of the enzyme. Proc Natl Acad Sci USA.1998;95: 12562-12567.

Park BW, Zhang HT, Wu C, Berezov A, Zhang X, Dua R, Wang Q, Kao G, O'Rourke DM, Greene MI, Murali R. Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo. Nat Biotechnol. 2000;18: 194-198.

Cheng X, Kinosaki M, Takami M, Choi Y, Zhang H, Murali, R. Disabling of receptor activator of nuclear factor-kappaB (RANK) receptor complex by novel osteoprotegerin-like peptidomimetics restores bone loss in vivo. J Biol Chem. 2004;279: 8269-8277.

Murali R, Cheng X, Berezov A, Du X, Schon A, Freire E, Xu X, Chen YH, Greene MI. Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107. Proc Natl Acad Sci USA. 2005;102: 10970-10975.

Zhou Z, Tone Y, Song X, Furuuchi K, Lear JD, Waldmann H, Tone M, Greene MI, Murali, R. Structural basis for ligand-mediated mouse GITR activation. Proc Natl Acad Sci USA. 2008;105:641-645.

Levine DH, Ghoroghchian PP, Freudenberg J, Zhang G, Therien MJ, Greene MI, Hammer DA, Murali, R. Polymersomes: A new multi-functional tool for cancer diagnosis and therapy. Methods. 2008;46: 25-32.

Srinivasan A, Ayyavoo V, Mahalingam S, Kannan A, Boyd A, Datta D, Kalyanaraman VS, Cristillo A, Collman R, Morellet N, Sawaya BE, Murali, R. A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: potential impact on CTL epitopes. Virology J. 2008;5: 99.

Ponde DE, Su Z, Berezov A, Zhang H, Alavi A, Greene MI, Murali, R. Development of anti-EGF receptor peptidomimetics (AERP) as tumor imaging agent. Bioorg Chem Med Letters. 2011;21: 2550-2553.

Berezov A, Cai Z, Freudenberg JA, Zhang H, Thompson T, Murali R, Greene MI, Wang Q. Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin. Oncogene. 2012;31, 1938-48.

Saha S, Pashov A, Monzavi-Karbassi B, Kieber-Emmons AM, Otaki A, Murali R, Kieber-Emmons T. Anticarbohydrate Antibodies: From molecular basis to clinical application. Editors: Kosma P and Muller-Loennies S. Springer Wein New York. Chapter 10. 229-254, (2012).