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Research in Magnetic Resonance Spectroscopy Lab focuses on the role of ectopic fat deposition in the development of obesity and associated complications such as type 2 diabetes. We developed, validated, and utilize methodology involving localized proton magnetic resonance spectroscopy (1H MRS) to quantitatively and noninvasively measure fat in human organs. This method offers a technological advantage as it distinguishes triglyceride in adipose tissue cells (where it belongs) from triglyceride droplets that are stored in the cytosol of parenchymal cells (where it does not belong). The non-invasive evaluation of parenchymal fat proved to be very successful originally in skeletal muscle and we modified localized 1H MRS procedure for applications in liver, pancreas, and the heart.