Publications
See a complete PubMed list of publications by Clive Svendsen, PhD.
Selected Key Publications
- Laperle A, Sances S, Yucer N, Dardov V, Garcia V, Ho R, Fulton A, Roxas K, Avalos P, Shu Z, Murali R, Maidment NT, Van Eyk J, Tagliati M, Svendsen CN. An iPSC model of early onset sporadic Parkinson’s disease reveals predictive biomarkers and potential therapeutic candidates. Nature Medicine. 2020;26(2):289-299.
- Vatine G, Barrile R, Workman M, Sances S, Barriga B, Rhamana M, Barthakur S, Kasendra M, Lucchesi C, Kerns J, Wen N, Chen Z, Van Eyk J, Hamilton G, Svendsen CN. Human iPSC-derived blood brain barrier-chip for disease modeling and personalized medicine applications. Cell Stem Cell. 2019;24(6):995-1005.e6.
- Das M, Godoy M, Chen S, Avalos P, Dang I, Yáñez A, Zhang W, Bresee C, Liu G, Svendsen CN*, Goodridge H. Young bone marrow transplantation preserves learning and memory in old mice. Communications Biology. 2019;2:73 *Corresponding Author
- Thomsen G, Avalos P, Ma A, Alkaslasi M, Wyss L, Vit JP, Godoy M, Suezaki P, Shelest O, Bankiewicz, K, Svendsen CN. Transplantation of neural progenitor cells expressing GDNF into the motor cortex as a strategy to treat amyotrophic lateral sclerosis. Stem Cells. 2018;36(7):1122-1131.
- Akhtar A, Kobritz N, Savinoff S, Garcia L, Tom C, Shelley B, Cho N, Gowing G, Mattis V, Breunig J, Svendsen CN. Doxycycline-mediated inducible and reversible expression of GDNF in transplanted iPSC-derived neural progenitors. Stem Cell Reports. 2018;10(6): 1696-1704.
- Sances S, Ho R, Vatine G, West D, Laperle A, Meyer A, Godoy M, Kay P, Mandefro B, Matata S, Hinojsa C, Wen N, Sareen D, Hamilton G, Svendsen CN. Human iPSC-derived endothelial cells and microengineered organ-chip enhance neuronal development. Stem Cell Reports. 2018;10(4):1222-1236.
- Rushton D, Andres P, Allred P, Baloh R, Svendsen CN. Patients with ALS show highly correlated progression rates in left and right limb muscles. Neurology. 2017;89(2):196-206.
- Vatine G, Al-Ahmad A, Barriga B, Svendsen S, Salim A, Garcia L, Garcia V, Ho R, Yucer N, Qian T, Lim R, Wu J, Thompson L, Spivia W, Chen Z, Van Eyke J, Palecek S, Refetoff S, Shuster E, Svendsen CN. Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier. Cell Stem Cell. 2017;20(6): 831-843.
- Yucer N, Holzapfel M, Vogel T, Lenaeus L, Ornelas L, Laury A, Sareen D, Barrett R, Karlan B, Svendsen CN. Directed differentiation of human induced pluripotent stem cells into fallopian tube epithelium. Scientific Reports. 2017;7(1):10741.
- Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016;16(4):542-553.
- Ho R, Sances S, Gowing G, Amoroso MW, O’Roarke JG, Shabian A, Wichterle H, Baloh RH, Sareen D, Svendsen CN. ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks. Nature Neurosci. 2016;19(9):1256-67.
- Das MM, Svendsen CN. Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. Neurobiol Aging. 2015;36(2):1130-1139.
- Thomsen GM, Gowing, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN. Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex. J Neurosci. 2014;34: 15587-600.
- Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L, Svendsen CN. Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate in the rodent spinal cord. J Comp Neurol. 2014;522: 2707-28.
- The Huntington’s Disease iPSC Consortium* Induced pluripotent stem cells from patients with Huntington's Disease show CAG repeat-associated phenotypes. Cell Stem Cell. 2012;11: 264-278 *Svendsen CN corresponding author.
- Ebert AD, Yu J, Rose F, Mattis VB, Lorson CL, Thomson JA, Svendsen CN. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature. 2009;457: 277-280.
- Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P, Svendsen CN. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Ther. 2006;13: 379-88.
- Klein SM, Suzuki M, Behrstock S, McHugh J, Hoffmann K, Wallace W, Aebischer P, Svendsen CN. GDNF Delivery using human neural progenitor cells in a rat model of ALS. Human Gene Therapy. 2005;16: 509-21.
- Gill SS, Patel NK, Hotton GR, O'Sullivan K, McCarter R, Bunnage M, Brooks DJ, Svendsen CN*, Heywood P. Direct brain infusion of glial cell line-derived neurotrophic factor (GDNF) in Parkinson's Disease. Nature Medicine. 2003;9: 589-595. *Corresponding Author
- Sofroneiw MV, Galletely NP, Isacson O, Svendsen CN. Survival of adult basal forebrain cholingergic neurons after loss of target neurons. Science. 1990;247: 338-342.
Contact the Svendsen Lab
127 S. San Vicente Blvd.
Pavilion, Room 8405
Los Angeles, CA 90048