Anastassiou Lab
The Anastassiou Laboratory studies how the molecular and cellular composition of neurons translates to their phenotype and how these properties combine in brain circuits to produce function or, in the case of disease, dysfunction.
The Anastassiou Lab has a broad background in multimodal cellular data (electrophysiology, anatomy, transcriptomics) and the development of state-of-the-art computational workflows (statistical learning, optimization and simulation) to understand cellular activity in behavior and disease. Uniquely, this work includes human brain tissue, both as a byproduct from surgery as well as from model systems such as human pluripotent stem cells. The Anastassiou Lab successfully pursues collaborations with clinicians to translate cellular and circuit findings to gain a better understanding of diseases such as epilepsy and Parkinson’s disease, as well as development of improved therapies.
The Anastassiou Lab is affiliated with the Cedars-Sinai Neurosurgery Department, Neurology Department, Center of Neural Sciences and Medicine and Regenerative Medicine Institute.
Personal Statement
Large biological datasets nowadays offer impeccable, cellular resolution in the makeup of the brain. Yet, how this cellular makeup impacts neural activity in the brain, in health or disease, remains largely enigmatic. We use a multidisciplinary approach blending biology, engineering, computer science and statistics to address these questions."
Costas Anastassiou, PhD
- Multimodal cellular data integration and reconciliation via optimization on high-performance computing architectures
- Next-generation technologies for monitoring physiology and pathophysiology activity in humans
- Next-generation electrical stimulation technologies for manipulating human cellular and circuit activity: toward new approaches to treating neurological and neuropsychiatric diseases
Publications
Learn more about the recent research publications from the Anastassiou Lab.