Chugh Lab

The Chugh Laboratory at the Smidt Heart Institute focuses on the prediction and prevention of sudden cardiac arrest. We use a large clinical data archive assembled over two decades from a catchment population of 1.85 million residents of Portland, Oregon, and Ventura, California. These well-phenotyped cohorts are connected to a biobank where we correlate phenotypes with whole genome and proteome findings using both conventional and artificial intelligence tools. We are testing our community-based discoveries in a separate longitudinal EHR cohort of approximately 400,000 residents of Los Angeles County. We are working toward designing new clinical trials to facilitate translation to the clinic as well as the community, to reduce the population burden of sudden cardiac arrest and sudden cardiac death.