Chute Lab
The Chute Lab focuses on discovering and characterizing novel mechanisms that regulate hematopoietic stem cell self-renewal and regeneration, emphasizing the role of the bone marrow vascular niche in determining hematopoietic stem cell fate. The lab utilizes state-of-the-art molecular techniques, high-resolution microscopy, bioinformatics and computational biology and innovative transgenic mouse models to study murine and human hematopoietic stem cell biology. Our findings reshape hematopoiesis understanding, guiding therapeutic strategies for stem cell regeneration and investigating regulatory pathways in leukemia. Our goal is translating discoveries into patient-focused therapeutics.
Personal Statement
I am a physician-scientist with specialized training in hematology, medical oncology and stem cell transplantation. Leading a basic research laboratory, we focus on discovering fundamental mechanisms controlling hematopoietic stem cell fate and the role of the niche in that process. Our contributions aim to redefine hematology, forming the foundation for new therapeutics promoting human hematopoietic regeneration and eradicating blood cancers.
John P. Chute, MD
Breakthrough Research
- The role of pleiotrophin in regulating hematopoietic stem cell fate
- The function of epidermal growth factor in promoting hematopoietic stem cell regeneration
- Contribution of Dkk1 in regulating hematopoietic regeneration in the niche
- Semaphorin 3A—NRP1 signaling in bone marrow vascular regeneration. Protein tyrosine phosphatase—sigma regulation of hematopoietic stem cell regeneration
- Cell-autonomous pleiotrophin regulation of human CML
Publications
Learn more about the recent research publications from the Chute Lab.
Laboratory Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Chute Lab, whose dedicated efforts lead to groundbreaking discoveries.
Job Opportunities
We are actively recruiting students and postdocs to be our colleagues and expand lab knowledge and expertise to make important breakthroughs.
Collaborations
The Chute Lab collaborates with a wide range of investigators within Cedars-Sinai and institutions around the world.
- Noble Lab
- Jeffrey Golden, MD
- Goodridge Lab
- Joshua P. Sasine, MD, PhD
- Regenerative Medicine Institute
- SOCCI Core Facilities
- Arjun Deb, UCLA
- Peter Bowers Lab, UCLA