Jefferies Lab
The Jefferies Lab is focused on understanding the role that RNA/DNA sensing mechanisms in monocytes and neutrophils play in driving autoimmune disease. The lab’s main area of focus is understanding these pathways in lupus, a debilitating, chronic autoimmune disease that presents as a broad spectrum of symptoms and manifestations. Patients with lupus have increased expression of interferon-stimulated genes (ISGs), a signature that correlates directly with disease activity. A feature of lupus is that women are more likely to get the disease; therefore, the Jefferies Lab is also studying how estrogen and steroid hormones affect these pathways.
Personal Statement
My goal is to uncover the fundamental mechanisms that lead to the development of lupus and discover ways to use this knowledge to better treat and manage this debilitating disease. To achieve this, I have focused on establishing strong working collaborations with leading rheumatologists, both in the U.S. and Ireland who specialize in lupus research.
Caroline Jefferies, PhD
Breakthrough Research
- Understanding the Interferon Signaling Pathway in Lupus Neutrophils
- Investigating Crosstalk Among Estrogen, RNA/DNA Sensing and IFN in the Immune Response in SLE
- Neutrophils, Endoplasmic Reticulum Stress and Lung Disease
Publications
Learn more about the recent research publications from the Jefferies Lab.
Laboratory Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Jefferies Lab, whose dedicated efforts lead to groundbreaking discoveries.
Job Opportunities
We are actively recruiting students and postdocs to be our colleagues and expand lab knowledge and expertise to make important breakthroughs.
Collaborations
The Jefferies Lab collaborates with a wide range of investigators within Cedars-Sinai and institutions around the world.
Contact the Jefferies Lab
8700 Beverly Blvd.
Davis Building, Room 5094E
Los Angeles, CA 90048