Publications
See a complete PubMed list of publications by Caroline Jefferies, PhD.
Selected Key Publications
- Smith S, Fernando T, Wu PW, Seo J, Ní Gabhann J, Piskareva O, McCarthy E, Howard D, O’Connell P, Conway R, Gallagher P, Molloy E, Stallings RL, Kearns G, Forbess L, Ishimori M, Venuturupalli S, Wallace D, Weisman M, Jefferies CA. MicroRNA-302d targets IRF9 to regulate the IFN-induced gene expression in SLE. J Autoimmun. 2017 May;79:105-111. http://www.sciencedirect.com/science/article/pii/S0896841117300653.
- McCarthy EM, Smith S, Lee RZ, Cunnane G, Doran MF, Donnelly S, Howard D, O'Connell P, Kearns G, Ní Gabhann J, Jefferies CA. The association of cytokines with disease activity and damage scores in systemic lupus erythematosus patients. Rheumatology (Oxford). 2014 Sep;53(9):1586-1594. https://academic.oup.com/rheumatology/article/53/9/1586/1872876
- Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan K, Spence S, Kissenpfennig A, Johnston JA, Fallon PG, Jefferies CA. Btk regulates macrophage polarization in response to lipopolysaccharide. PLOS ONE. 2014 Jan 21;9(1):e85834. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085834.
- Smith S, Ní Gabhann J, McCarthy E, Coffey B, Mahony R, Byrne JC, Stacey K, Ball E, Bell A, Cunnane G, Doran MF, Molloy ES, Lee RZ, Harvey B, Kearns G, Jefferies CA. Estrogen receptor α regulates tripartite motif-containing protein 21 expression, contributing to dysregulated cytokine production in systemic lupus erythematosus. Arthritis Rheumatol. 2014 Jan;66(1):163-172. http://onlinelibrary.wiley.com/doi/10.1002/art.38187/full.
- Lazzari E, Korczeniewska J, Ní Gabhann J, Smith S, Barnes BJ, Jefferies CA. TRIpartite motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms. PLOS ONE. 2014 Aug 1;9(8):e103609. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103609.
- Wynne C, Lazzari E, Smith S, McCarthy EM, Ní Gabhann J, Kallal LE, Higgs R, Greco A, Cryan SA, Biron CA, Jefferies CA. TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems. PLOS ONE. 2014 Jul 7;9(7):e101503. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101503.
- Byrne JC, Ní Gabhann J, Stacey KB, Coffey BM, McCarthy E, Thomas W, Jefferies CA. Bruton's tyrosine kinase is required for apoptotic cell uptake via regulating the phosphorylation and localization of calreticulin. J Immunol. 2013 May 15;190(10):5207-5215. http://www.jimmunol.org/content/190/10/5207.
- McCarthy EM, Lee RZ, Ní Gabhann J, Smith S, Cunnane G, Doran MF, Howard D, O'Connell P, Kearns G, Jefferies CA. Elevated B lymphocyte stimulator levels are associated with increased damage in an Irish systemic lupus erythematosus cohort. Rheumatology (Oxford). 2013 Jul;52(7):1279-1284. https://academic.oup.com/rheumatology/article/52/7/1279/1793615
- Smith S, Gabhann JN, Higgs R, Stacey K, Wahren-Herlenius M, Espinosa A, Totaro MG, Sica A, Ball E, Bell A, Johnston J, Browne P, O'Neill L, Kearns G, Jefferies CA. Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus. Arthritis Rheum. 2012 May;64(5):1601-1609. http://onlinelibrary.wiley.com/doi/10.1002/art.33494/abstract.
- Ní Gabhann J, Spence S, Wynne C, Smith S, Byrne JC, Coffey B, Stacey K, Kissenpfennig A, Johnston J, Jefferies CA. Defects in acute responses to TLR4 in Btk-deficient mice result in impaired dendritic cell-induced IFN-γ production by natural killer cells. Clin Immunol. 2012 Mar;142(3):373-382. http://www.sciencedirect.com/science/article/pii/S1521661611003500.
- Stacey KB, Breen E, Jefferies CA. Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity. PLOS ONE. 2012;7(3):e34041. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034041.
- Jefferies C, Wynne C, Higgs R. Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease? Nat Rev Immunol. 2011 Aug 25;11(9):617-625. http://www.nature.com/nri/journal/v11/n9/full/nri3043.html.
- Higgs R, Lazzari E, Wynne C, Ní Gabhann J, Espinosa A, Wahren-Herlenius M, Jefferies CA. Self protection from anti-viral responses—Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors. PLOS ONE. 2010 Jul 26;5(7):e11776. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011776.
- Gabhann JN, Higgs R, Brennan K, Thomas W, Damen JE, Ben Larbi N, Krystal G, Jefferies CA. Absence of SHIP-1 results in constitutive phosphorylation of tank-binding kinase 1 and enhanced TLR3-dependent IFN-beta production. J Immunol. 2010 Mar 1;184(5):2314-2320. http://www.jimmunol.org/content/184/5/2314.
- Espinosa A, Dardalhon V, Brauner S, Ambrosi A, Higgs R, Quintana FJ, Sjöstrand M, Eloranta ML, Ní Gabhann J, Winqvist O, Sundelin B, Jefferies CA, et al. Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J Exp Med. 2009 Aug 3;206(8):1661-1671. https://rupress.org/jem/article/206/8/1661/40397/Loss-of-the-lupus-autoantigen-Ro52-Trim21-induces
Contact the Jefferies Lab
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Davis Building, Room 5094E
Los Angeles, CA 90048