Publications

• Chu HL, Indramohan M, Ratsaimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A*, Stehlik C*. The oxidized phospholipid oxPAPC protects from septic shock by targeting non-canonical inflammasome in macrophages. Nat Commun. 2018 Mar 8;9(1):996.
• Ratsimandresy R, Chu HL, Indramohan M, Gangopadhyay A, Dorfleutner A*, Stehlik C*. The PYRIN domain-only protein POP2 regulates inflammasome priming and activation. Nat Commun. 2017 Jun 5;8:15556.
• Ratsimandresy R, Indramohan M, Dorfleutner A*, Stehlik C*. The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cell Mol Immunol. 2017 Jan;14:127-142.
• de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy R, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A*, Stehlik C*. The PYRIN domain-only protein POP1 inhibits inflammasome assembly and ameliorates inflammatory disease. Immunity. 2015 Aug 18;43(2):264-276.
• Dorfleutner A, Chu L, Stehlik C. Inhibiting the inflammasome: one domain at a time. Immunol Rev. 2015 May;265(1):205-216.
• Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A*, Stehlik C*. The PYRIN domain-only protein POP3 inhibits AIM2-like receptor inflammasomes and regulates responses to DNA virus infections. Nat Immunol. 2014 Apr;15(4):343-345.
• Khare S, Dorfleutner A, Bryan NB, Yun C, Radian AD, de Almeida L, Rojanasakul Y, Stehlik C. An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. Immunity. 36, 464-476 (2012)
• Bryan NB, Dorfleutner A, Rojanasakul Y, Stehlik C. Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain. J Immunol. 2009 Mar 1;182(5):3173-3182.
• Stehlik C, Dorfleutner A. COPs and POPs: modulators of inflammasome activity. J Immunol. 2007 Dec 15;179:7993-7998.

*Co-corresponding author