Sasine Lab
We seek to discover new therapeutic interventions to improve the lives of patients with multiple myeloma, an incurable cancer of antibody-secreting plasma cells. To accomplish our goal, we use modern molecular biology methods, in vitro and in vivo models, primary patient samples and clinical trial correlative data. We are especially interested in paracrine signaling within the bone marrow, how this drives cancer progression and how it can be therapeutically leveraged.
Personal Statement
As a physician-scientist, I strive to use scientific tools to better understand hematologic cancers in order to develop tools which will benefit patients. I am particularly interested in cellular therapy, macromolecular delivery, paracrine regulators in the bone marrow microenvironment."
Joshua P. Sasine, MD, PhD
Breakthrough Research Areas
- Multiple myeloma interactions with the vascular endothelium
- Paracrine regulators of multiple myeloma
- Hematopoietic stem cell expansion
- Cellular-derived nucleic acid therapeutics for cancer
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Sasine Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Gaut D, Tang K, Sim MS, Duong T, Young P, Sasine J.
Int J Cancer. 2021 Mar 1;148(5):1192-1196.
Pasquini MC, Hu ZH, Curran K, Laetsch T, Locke F, Rouce R, Pulsipher MA, Phillips CL, Keating A, Frigault MJ, Salzberg D, Jaglowski S, Sasine JP, Rosenthal J, Ghosh M, Landsburg D, Margossian S, Martin PL, Kamdar MK, Hematti P, Nikiforow S, Turtle C, Perales MA, Steinert P, Horowitz MM, Moskop A, Pacaud L, Yi L, Chawla R, Bleickardt E, Grupp S.
Blood Adv. 2020 Nov 10;4(21):5414-5424.
Gaut D, Burkenroad A, Duong T, Feammelli J, Sasine J, Schiller G.
Leuk Res. 2020 Mar;90:106314.
Contact the Sasine Lab
8700 Beverly Blvd.
Pavilion, Suite 8110B
Los Angeles, CA 90048