Publications
See a complete PubMed list of publications by Mark Goodarzi, MD, PhD.
Selected Key Publications
- Goodarzi MO. Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications. Lancet Diabetes Endocrinol. 2018 Mar;6(3):223-236. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(17)30200-0/fulltext.
- Jones MR, Brower MA, Xu N, Cui J, Mengesha E, Chen YDI, Taylor KD, Azziz R, Goodarzi MO. Systems genetics reveals the functional context of PCOS loci and identifies genetic and molecular mechanisms of disease heterogeneity. PLOS Genet. 2015 Aug 25;11(8):e1005455. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005455.
- Brower MA, Jones MR, Rotter JI, Krauss RM, Legro RS, Azziz R, Goodarzi MO. Further investigation in Europeans of susceptibility variants for polycystic ovary syndrome discovered in genome-wide association studies of Chinese individuals. J Clin Endocrinol Metab. 2015 Jan;100(1):E182-186. https://academic.oup.com/jcem/article/100/1/E182/2812908
- Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert MF, Raghavan S,… Goodarzi MO. Low-frequency and rare exome chip variants associate with fasting glucose and Type 2 diabetes susceptibility. Nat Commun. 2015 Jan;29(6):5897. https://www.nature.com/articles/ncomms6897.
- Palmer ND*, Goodarzi MO*, Langefeld CD*, Wang N*, Guo X, Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH, et al. Genetic variants associated with quantitative glucose homeostasis traits translate to Type 2 diabetes in Mexican Americans: the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Diabetes. 2015 May;64(5):1853-1866. *Equal first author status. https://diabetesjournals.org/diabetes/article/64/5/1853/40512/Genetic-Variants-Associated-With-Quantitative
- Goodarzi MO, Li X, Krauss RM, Rotter JI, Chen YDI. Relationship of sex to diabetes risk in statin trials. Diabetes Care. 2013 Jul;36(7):e100-101. https://diabetesjournals.org/care/article/36/7/e100/33278/Relationship-of-Sex-to-Diabetes-Risk-in-Statin
- Goodarzi MO, Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YDI, Taylor KD, Buchanan TA, Hsueh WA, et al. Systematic evaluation of validated Type 2 diabetes and glycemic trait loci for association with insulin clearance. Diabetologia. 2013 Jun;56(6):1282-1290. http://link.springer.com/article/10.1007%2Fs00125-013-2880-6.
- Lee CC, Haffner SM, Wagenknecht LE, Lorenzo C, Norris JM, Bergman RN, Stefanovski, Anderson AM, Rotter JI, Goodarzi MO*, Hanley AJG*. Insulin clearance and the incidence of Type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. Diabetes Care. 2013 Apr;36(4):901-907. *Equal senior author status. https://diabetesjournals.org/care/article/36/4/901/37976/Insulin-Clearance-and-the-Incidence-of-Type-2
- Jones MR, Chazenbalk G, Xu N, Chua A, Eigler T, Mengesha E, Chen YH, Lee JM, Pall M, Li X, Chen YD, Taylor KD, Mathur R, Krauss RM, Rotter JI, Legro RS, Azziz R, Goodarzi MO. Steroidogenic regulatory factor FOS is underexpressed in polycystic ovary syndrome (PCOS) adipose tissue and genetically associated with PCOS susceptibility. J Clin Endocrinol Metab. 2012 Sep;97(9):E1750-1757. https://academic.oup.com/jcem/article/97/9/E1750/2536604.
- Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YD, Taylor KD, Buchanan TA, Davis RC, Hsueh WA, Raffel LJ, Rotter JI, Goodarzi MO. Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis. Diabetologia. 2012 Aug;55(8):2183-2192. http://link.springer.com/article/10.1007%2Fs00125-012-2577-2.
- Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz J, et al. CRTC3 links catecholamine signaling to energy balance. Nature. 2010 Dec 16;468(7326):933-939. https://www.nature.com/articles/nature09564.
- Rich SS*, Goodarzi MO*, Palmer ND, Langefeld CD, Ziegler J, Haffner SM, Bryer-Ash M, Norris JM, Taylor KD, Haritunians T, et al. A genome-wide association scan for acute insulin response to glucose in Hispanic Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). Diabetologia. 2009 Jul;52(7):1326-1333. *Equal first author status. http://link.springer.com/article/10.1007%2Fs00125-009-1373-0.
- Goodarzi MO, Jones MR, Chen YDI, Azziz R. First evidence of genetic association between AKT2 and polycystic ovary syndrome. Diabetes Care. 2008 Dec;31(12):2284-2287. https://diabetesjournals.org/care/article/31/12/2284/24920/First-Evidence-of-Genetic-Association-Between-AKT2
- Goodarzi MO, Lehman DM, Taylor KD, Guo X, Cui J, Quiñones MJ, Clee SM, Yandell BS, Blangero J, Hsueh WA, et al. SORCS1: a novel human Type 2 diabetes susceptibility gene suggested by the mouse. Diabetes. 2007 Jul;56(7):1922-1929. https://diabetesjournals.org/diabetes/article/56/7/1922/12583/SORCS1-A-Novel-Human-Type-2-Diabetes
- Goodarzi MO, Taylor KD, Guo X, Quiñones MJ, Cui J, Li X, Hang T, Yang H, Holmes E, Hsueh WA, et al. Variation in the gene for muscle-specific adenosine monophosphate deaminase is associated with insulin clearance, a highly heritable trait. Diabetes. 2005 Apr;54(4):1222-1227. https://diabetesjournals.org/diabetes/article/54/4/1222/14844/Variation-in-the-Gene-for-Muscle-Specific-AMP
Contact the Goodarzi Lab
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Davis Building, Room 3008
Los Angeles, CA 90048