Mun Lab

The Mun Lab focuses on developing patient-derived organs-on-chips and bioengineered 3D organs as in vitro models mimicking in vivo structures to understand the physiology and pathophysiology of mucociliary clearance in cystic fibrosis (CF) patients. Using 3D bioprinting technology, the Mun Lab has successfully developed a 3D human lung airway composed of lung fibroblasts with complex networks of differentiated lung airway epithelial cells, including ciliary cells and goblet cells. Bioengineered cell culture models help monitor cellular function and cell-cell interaction, allowing researchers to screen drugs and test drug toxicity for drug discovery. The Mun Lab also developed a novel in vitro co-culturing model, pancreas-on-a-chip, to study cystic fibrosis-related diabetes (CFRD)—one of the most typical and fatal complications in CF patients.