Pulmonary Postdoctoral Training Program
The Lung Program is a hub for training and developing the next generation of pulmonary scientists and physician investigators. Investigators from Pulmonary Research have active and productive interactions with local colleagues at the University of Southern California and UCLA, as well as with top programs throughout the world.
About Postdoctoral Pulmonary Training
The training is focused on developing young biomedical researchers into independent academic investigators dedicated to studies in respiratory diseases. Cedars-Sinai has been in an academic growth phase, with a large influx of investigators all with well-recognized respiratory research programs. Importantly, these investigators are highly interactive and dedicated to training the future generation of respiratory researchers and bring an established track record of training to the Women's Guild Lung Institute at Cedars-Sinai. This training program is directed by Paul Noble, MD, who is the chair of the Department of Medicine and director of the Women's Guild Lung Institute.
Positions are available for scientists to train in basic and translational respiratory research. Trainees have a structured three-year curriculum based primarily in laboratory research and complemented with didactic courses, seminars and workshops. The coursework provides instruction on topics such as research integrity and bioethics, biostatistics and grantsmanship. Trainees have a primary mentor (often coupled with a co-mentor) to guide their research training in five areas:
- Inflammation and host defense
- Remodeling and fibrosis
- Immunology
- Regeneration
- Cancer
Position Requirements
The Pulmonary Research Training Program is seeking motivated, talented individuals with relevant interests and experience to join our multidisciplinary team of researchers. Because a National Institutes of Health (NIH) Institutional Training Grant supports these positions, all applicants must have an MD, PhD, DVM, DDS or similar degree and must be a U.S. citizen or possess permanent residence status.
How to Apply
Please submit curriculum vitae (CV), a personal statement with a brief summary of research experience, a list of faculty of interest, approximate date of availability and three references to:
Attn: Sabriya Hughes
Multidisciplinary Pulmonary Research Training Program
Women's Guild Lung Institute
Cedars-Sinai
127 S. San Vicente Blvd.
Pavilion, Room 9400
Los Angeles, CA 90048
Participating Laboratories & Researchers
(NLRP3 inflammasome activation in pulmonary infections, the role of infections such as Chlamydia pneumonia in inducing asthma)
(dysregulation of GSH synthesis in liver injury and fibrosis, Prohibin in liver injury and cancer)
(angiotensin-converting enzyme regulation of the immune response, angiotensin-converting enzyme control of MHC class I peptide processing, angiotensin-converting enzyme regulation of tumor cell growth)
(molecular mechanisms of lung fibrogenesis, determinants in progenitor cell survival in IPF)
(immune mechanisms that regulate fungal and viral signals, innate DNA sensing in rapidly progressing IPF, immune mechanisms that regulate fungal and viral signals, senescence-induced oncogenesis in IPF)
(lung regeneration after influenza infection, epithelial defects that contribute to the development of fibrotic lung disease, defining mechanisms of normal tissue maintenance and repair following injury, alterations in single-cell phenotypes during lung carcinogenesis)
(role of beta-arrestins in lung injury and fibrosis, determinants in progenitor cell survival in IPF)
Representative Publications of Ongoing Areas of Research
Shibata T, Ismailoglu UB, Kittan NA, Moreira AP, Coelho AL, Chupp GL, Kunkel SL, Lukacs NW, Hogaboam CM. Role of growth arrest–specific gene 6 in the development of fungal allergic airway disease in mice. Am J Respir Cell Mol Biol. 2014;51(5):615-625.
Huang Y, Ma SF, Espindola MS, Vij R, Oldham JM, Huffnagle GB, Erb-Downward JR, Flaherty KR, Moore BB, White ES, Zhou T, Li J, Lussier YA, Han MK, Kaminski N, Garcia JGN, Hogaboam CM, Martinez FJ, Noth I; COMET-IPF Investigators. Microbes are associated with host innate immune response in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2017 Jul 15;196(2):208-219.
Brauer R, Ge L, Schlesinger SY, Birkland TP, Huang Y, Parimon T, Lee V, McKinney BL, McGuire JK, Parks WC, Chen P. Syndecan-1 attenuates lung injury during influenza infection by potentiating c-Met signaling to suppress epithelial apoptosis. Am J Respir Crit Care Med. 2016;194(3):333-344.
Secor PR, Sweere J, Michaels LA, Malkovskiy AV, Lazzareschi D, Katznelson E, Arrigoni A, Braun KR, Evanko SP, Kaminsky W, Singh PK, Parks WC, Bollyky PL. Filamentous bacteriophage promote biofilm assembly and tolerance to desiccation and antibiotics. Cell Host Microbe. 2015;18(5):549-559.
McConnell AM, Yao C, Yeckes AR, Wang Y, Selvaggio AS, Tang J, Kirsch DG, Stripp BR. p53 regulates progenitor cell quiescence and differentiation in the airway. Cell Rep. 2016;17:2173-2182.
IyerSS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier A, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL, Sutterwala FS. Mitochondrial cardiolipin regulates Nlrp3 inflammasome activation. Immunity. 2013;39(2):311-323.
Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW. Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis. J Clin Invest. 2016 Aug 1;126(8):3063-3079.
Ge L, Habiel DM, Hansbro PM, Kim RY, Gharib SA, Edelman JD, Königshoff M, Parimon T, Brauer R, Huang Y, Allen J, Jiang D, Kurkciyan AA, Mizuno T, Stripp BR, Noble PW, Hogaboam CM, Chen P. miR-323a-3p regulates lung fibrosis by targeting multiple pro-fibrotic pathways. JCI Insight. 2016. 1(20):e90301.
McMahan RS, Birkland TP, Smigiel KS, Vandivort TC, Rohani MG, Manicone AM, McGuire JK, Gharib SA, Parks WC. Stromelysin-2 (MMP10) moderates inflammation by controlling macrophage activation. J Immunol. 2016 Aug 1;197(3):899-909.
Ulland TK, Jain N, Hornick EE, Elliott EI, Clay GM, Sadler JJ, Mills KA, Janowski AM, Volk AP, Wang K, Legge KL, Gakhar L, Bourdi M, Ferguson PJ, Wilson ME, Cassel SL, Sutterwala FS. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016 Oct 25;7:13180.
Liang J, Zhang Y, Xie T, Liu N, Chen H, Geng Y, Kurkciyan A, Mena JM, Stripp BR, Jiang D, Noble PW. Hyaluronanand TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice. Nat Med. 2016 Nov;22(11):1285-1293.
Ray S, Chiba N, Yao C, Guan X, McConnell AM, Brockway B, Que L, McQualter JL, Stripp BR. Rare SOX2+ airway progenitor cells generate KRT5+ cells that repopulate damaged alveolar parenchyma following influenza virus infection. Stem Cell Reports. 2016 Nov 8;7(5):817-825.
Have Questions or Need Help?
Contact us if you have questions or would like to learn more about Cedars-Sinai's Postdoctoral Scientist Training Program.
Emma Yates Casler
Program Manager