Publications
See a complete PubMed list of publications by Simon Gayther, PhD.
Selected Key Publications
- Manek R, Pakzamir E, Mhawech-Fauceglia P, Pejovic T, Sowter H, Gayther SA, Lawrenson K. Targeting Src in endometriosis-associated ovarian cancer. Oncogenesis. 2016 Aug;5(8):e251. http://www.nature.com/oncsis/journal/v5/n8/full/oncsis201654a.html.
- Adler EK, Mhawech-Fauceglia P, Gayther SA, Lawrenson, K. PAX8 expression in ovarian surface epithelial cells. Hum Pathol. 2015 Jul;46(7):948-956. http://www.humanpathol.com/article/S0046-8177(15)00121-5/abstract.
- Lawrenson K, Lee N, Torres HA, Lee JM, Brueggmann D, Rao N, Noushmehr H, Gayther SA. Src as a novel therapeutic target for endometriosis. Gynecol Oncol. 2014 Oct;135(1):100-107. http://www.gynecologiconcology-online.net/article/S0090-8258(14)01056-7/abstract.
- Li Q, Stram A, Chen C, Kar S, Gayther S, Pharoah P, Haiman C, Stranger B, Kraft P, Freedman ML. Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types. Hum Mol Genet. 2014 Oct 1;23(19):5294-5302. https://academic.oup.com/hmg/article/23/19/5294/2900770
- Brueggmann D, Templeman C, Starzinski-Powitz A, Rao NP, Gayther SA, Lawrenson K. Novel three-dimensional in vitro models of ovarian endometriosis. J Ovarian Res. 2014 Feb 6;7:17. http://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-7-17.
- Lee J, Mhawech-Fauceglia P, Lee N, Parsanian JC, Lin YG, Gayther SA, Lawrenson K. A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro. Lab Invest. 2013 May;93(5):528-542. http://www.nature.com/labinvest/journal/v93/n5/full/labinvest201341a.html.
- Freedman ML, Monteiro AN, Gayther SA, Coetzee GA, Risch A, Plass C, Casey G, De Biasi M, Carlson C, Duggan D, et al. Principles for the post-GWAS functional characterization of cancer risk loci. Nat Genet. 2011 Jun;43(6):513-518. http://www.nature.com/ng/journal/v43/n6/full/ng.840.html.
- Lawrenson K, Grun B, Benjamin E, Jacobs IJ, Dafou D, Gayther SA. Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer. Neoplasia. 2010 Apr;12(4):317-325. http://www.sciencedirect.com/science/article/pii/S1476558610800107.
- Lawrenson K, Benjamin E, Jacobs IJ, Gayther SA, Dafou D. In vitro three-dimensional modeling of human ovarian surface epithelial cells. Cell Prolif. 2009 Jun;42(3):385-393. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2184.2009.00604.x/abstract.
- Khalique L, Ayhan A, Whitaker JC, Singh N, Jacobs IJ, Gayther SA, Ramus SJ. The clonal evolution of metastases from primary serous epithelial ovarian cancers. Int J Cancer. 2009 Apr 1;124(7):1579-1586. http://onlinelibrary.wiley.com/doi/10.1002/ijc.24148/abstract.
- Grun B, Benjamin E, Sinclair J, Timms, JF, Jacobs IJ, Gayther SA, Dafou D. Three-dimensional in vitro cell biology models of ovarian and endometrial cancer. Cell Prolif. 2009 Apr;42(2):219-228. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2184.2008.00579.x/abstract.
- Høgdall EV, Christensen L, Høgdall CK, Frederiksen K, Gayther S, Blaakaer J, Jacobs IJ, Kjaer SK. Distribution of p53 expression in tissue from 774 Danish ovarian tumour patients and its prognostic significance in ovarian carcinomas. APMIS. 2008 May;116(5):400-409. http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0463.2008.00917.x/abstract.
- Khalique L, Ayhan A, Weale ME, Jacobs IJ, Ramus SJ, Gayther SA. Genetic intra-tumour heterogeneity in epithelial ovarian cancer and its implications for molecular diagnosis of tumours. J Pathol. 2007 Feb;211(3):286-295. http://onlinelibrary.wiley.com/doi/10.1002/path.2112/abstract.
- Högdall EV, Christensen L, Högdall CK, Blaakaer J, Gayther SA, Jacobs IJ, Christensen IBJ, Kjaer SK. Prognostic value of estrogen receptor and progesterone receptor tumor expression in Danish ovarian cancer patients: from the 'MALOVA' ovarian cancer study. Oncol Rep. 2007 Nov;18(5):1051-1059. https://www.spandidos-publications.com/or/18/5/1051.
- Brinkmann D, Ryan A, Ayhan A, McCluggage WG, Feakins R, Santibanez-Koref MF, Mein CA, Gayther SA, Jacobs IJ. A molecular genetic and statistical approach for the diagnosis of dual-site cancers. J Natl Cancer Inst. 2004 Oct 6;96(19):1441-1446. https://academic.oup.com/jnci/article/96/19/1441/2905462
Genetic Epidemiology and Variant Discovery Working Group Publications
See a complete PubMed list of publications by Michelle Jones, PhD.
Selected Key Publications
- Jones MR, Goodarzi MO. Genetic determinants of polycystic ovary syndrome: progress and future directions. Fertil Steril. 2016 Jul;106(1):25-32. http://www.fertstert.org/article/S0015-0282(16)61137-8/abstract.
- Jones MR, Brower M, Xu N, Cui J, Mengesha E, Chen Y-D, Taylor KD, Azziz R, Goodarzi MO. Systems genetics reveals the functional context of PCOS loci and identifies genetic and molecular mechanisms of disease heterogeneity. PLOS Genet. 2015 Aug 25;11(8):e1005455. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005455.
- Brower MA, Jones MR, Rotter JI, Krauss RM, Legro RS, Azziz R, Goodarzi MO. Further investigation in Europeans of susceptibility variants for polycystic ovary syndrome discovered in genome-wide association studies of Chinese individuals. J Clin Endocrinol Metab. 2015 Jan;100(1):e182-186. https://academic.oup.com/jcem/article/100/1/E182/2812908
- Huertas-Vazquez A, Nelson CP, Guo X, Reinier K, Uy-Evanado A, Teodorescu C, Ayala J, Jerger K, Chugh H, WTCCC+, Braund PS, Deloukas P, Hall AS, Balmforth AJ, Jones M, et al. Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease. PLOS One. 2013 Apr 4;8(4):e59905. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059905.
- Goodarzi MO, Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YD, Taylor KD, Buchanan TA, Hsueh WA, et al. Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance. Diabetologia. 2013 Jun;56(6):1282-1290. http://link.springer.com/article/10.1007%2Fs00125-013-2880-6.
Functional Genomics and GWAS Working Group Publications
- Rebbeck TR, Friebel TM, Mitra N, Wan F, Chen S, Andrulis IL, Apostolou P, Arnold N, Arun BK, Barrowdale D, et al. Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women. Breast Cancer Res. 2016 Nov 11:18(1):112. https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-016-0768-3.
- Plummer JT, Gordon AJ, Levitt P. The genetic intersection of neurodevelopmental disorders and shared medical comorbidities — relations that translate from bench to bedside. Front Psychiatry. 2016 Sep 30;7:142. http://journal.frontiersin.org/article/10.3389/fpsyt.2016.00142/full.
- Talhouk A, Kommoss S, Mackenzie R, Cheung M, Leung S, Chiu DS, Kalloger SE, Huntsman DG, Chen S, Intermaggio M, et al. Single-patient molecular testing with NanoString nCounter data using a reference-based strategy for batch effect correction. PLOS One. 2016;11(4):e0153844. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153844.
- Plummer JT, Evgrafov OV, Bergman MY, Friez M, Haiman CA, Levitt P, Aldinger KA. Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome. Transl Psychiatry. 2013 Oct 22;3:e316. http://www.nature.com/tp/journal/v3/n10/full/tp201391a.html.
- Levine AJ, Ihenacho U, Lee W, Figueiredo JC, Vandenberg DJ, Edlund CK, Davis BD, Stern MC, Haile RW. Genetic variation in insulin pathway genes and distal colorectal adenoma risk. Int J Colorectal Dis. 2012 Dec;27(12):1587-1595. doi: 10.1007/s00384-012-1505-8. http://link.springer.com/article/10.1007%2Fs00384-012-1505-8.
Contact the Gayther Lab
8700 Beverly Blvd.
Steven Spielberg Building, Room 155
Los Angeles, CA 90048