Braun Lab
Distinguishing fecal metabolites in predisease Crohn's disease susceptible (upper) and resistant (lower) microbiome ecologies. From Jacobs J et al., Cell Mol Gastroenterol Hepatol. 2016 2:750.
Research in the Braun Laboratory involves the biology of mucosal-microbiome interaction and its impact on chronic mucosal inflammatory disease and cancer. The Braun Lab investigates the colon and how host genetics and mucosal microbial ecology shape intestinal immunoregulation, inflammatory bowel pathogenesis and intestinal carcinogenesis. This work is based in both human cohorts and in model and gnotobiotic mouse systems using innovative 'omic and bioinformatics-based approaches (functional immune assessment, tissue proteomics, genome-wide genetics and microbiome metagenomics and metabolomics).
The Braun Lab is led by Jonathan Braun, MD, PhD, whose activities include member or principal investigator roles in the National Institute of Diabetes and Digestive and Kidney Diseases Inflammatory Bowel Disease (IBD) Genetics Consortium, National Institutes of Health Human Microbiome Project 2, and Crohn's & Colitis Foundation Microbiome Consortium. The work has identified allelic variation of IBD-associated loci in microbiome composition and function, characterization of disease-associated microbial metabolites contributing to the mucosal inflammatory state and mechanisms of predisease and disease activity states of the microbiome.
The Braun Laboratory is affiliated with the Cedars-Sinai Inflammatory Bowel and Immunobiology Research Institute and Department of Biomedical Sciences.
Personal Statement
Cedars-Sinai and, in particular, the Inflammatory Bowel and Immunobiology Research Institute (IBIRI) is a fertile environment to expand my studies of inflammatory diseases affected by the microbiome and accelerate the application of the discoveries to patient care. As the former Chair of the UCLA Department of Pathology and Laboratory Medicine, I have operational experience and insight to even further enhance the capacity and streamline the existing scientific infrastructure of IBIRI. As chair and member of multiple scientific advisory committees in the U.S. and overseas, I am afforded the opportunity to review and prioritize ongoing scientific efforts and building consensus and consortia to approach complex disease processes such as inflammatory bowel disease.
Jonathan Braun, MD, PhD
Breakthrough Research Areas
- The Metaproteome: Assessing Microbiome Ecology From its Protein Features
- Rosetta: Imputing Intestinal Microbiome Composition and Function from the Plasma Metabolome
- Epithelial Autoimmunity in IBD Pathogenesis
Collaborations & Resources
Collaborations
- Arditi Laboratory
- Barrett Laboratory
- Board of Governors Regenerative Medicine Institute
- Suzanne Devkota, PhD
- Phillip R. Fleshner, MD
- Gonsky Laboratory
- IBD Drug Discovery and Development Unit
- Inflammatory Bowel and Immunobiology Research Institute
- McGovern Laboratory
- Gil Melmed, MD
- Michelsen Laboratory
- MIRIAD IBD Biobank
- Precision Health
- Surgery Department
- Svendsen Laboratory
- Underhill Laboratory
- Van Eyk Laboratory
- David Casero, PhD
Reagents and Resources
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Braun Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Publications
Limon JJ, Tang J, Li D, Wolf AJ, Michelsen KS, Funari V, Gargus M, Nguyen C, Sharma P, Maymi VI, Iliev ID, Skalski JH, Brown J, Landers C, Borneman J, Braun J, et al.
Cell Host Microbe. 2019 Mar 13;25(3):377-388.e6.
Chang YL, Rossetti M, Vlamakis H, Casero D, Sunga G, Harre N, Miller S, Humphries R, Stappenbeck T, Simpson K, Sartor RB, Wu GD, Lewis J, Bushman F, McGovern DPB, Salzman N, Borneman J, Xavier R, Huttenhower C, Braun J.
Mucosal Immunol. 2019 Mar;12(2):457-467.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh M, Braun J, et al.
Immunity. 2019 Jan 15;50(1):212-224.e4.
Contact the Braun Lab
110 George Burns Road
Davis Building, Room D4063
Los Angeles, CA 90048