Publications
See a complete PubMed list of publications by Megan Hitchins, PhD.
Selected Key Publications
- Kuroiwa-Trzmielina J, Wang F, Rapkins RW, Ward RL, Buchanan DD, Win AK, Clendenning M, Rosty C, Southey MC, Winship IM, Hopper JL, Jenkins MA, Olivier J, Hawkins NJ, Hitchins MP. SNP rs16906252C>T is an expression and methylation quantitative trait locus associated with an increased risk of developing MGMT-methylated colorectal cancer. Clin Cancer Res. 2016 Dec 15;22(24):6266-6277. https://aacrjournals.org/clincancerres/article/22/24/6266/257361/SNP-rs16906252C-gt-T-Is-an-Expression-and
- Lynch HT, Snyder C, Shaw T, Heinen CD, Hitchins MP. Milestones of Lynch syndrome: 1895-2015. Nat Rev Cancer. 2015 Mar;15(3):181-194. https://www.nature.com/articles/nrc3878.
- Hitchins MP. Constitutional epimutation as a mechanism for cancer causality and heritability? Nat Rev Cancer. 2015 Oct;15(10):625-634. https://www.nature.com/articles/nrc4001.
- Rapkins RW, Wang F, Nguyen HN, Cloughesy TF, Lai A, Ha W, Nowak AK, Hitchins MP, McDonald KL. The MGMT promoter SNP, rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide.Neuro Oncol. 2015 Dec;17(12):1589-1598. https://academic.oup.com/neuro-oncology/article/17/12/1589/2509031
- Thompson BA, Spurdle AB, Plazzer JP, Greenblatt MS, Akagi K, Al-Mulla F, Bapat B, Bernstein I, Capellá G, den Dunnen JT, du Sart D, Fabre A, Farrell MP, Farrington SM, Frayling IM, Frebourg T, Goldgar DE, Heinen CD, Hitchins M, et al. Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database. Nat Genet. 2014 Feb;46(2):107-115. https://www.nature.com/articles/ng.2854.
- Kwok CT, Vogelaar IP, van Zelst-Stams W, Mensenkamp A, Ligtenberg M, Rapkins RW, WardRL, Chun N, Ford JM, LadabaumU, McKinnon WC, Greenblatt MS, Hitchins MP. The MLH1 c.-27C>A and c.85G>T variants are linked to dominantly inherited MLH1 epimutation and are borne on a European ancestral haplotype.Eur J Hum Genet. 2014 May;22(5):617-624. https://www.nature.com/articles/ejhg2013200.
- Ward RL, Dobbins T, Lindor NM, Rapkins RW, Hitchins MP. Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry. Genet Med. 2013;15(1):25-35. https://www.nature.com/articles/gim201291
- Hitchins MP, Rapkins R, Kwok CT, Srivastava S, Wong JJL, Khachigian LM, Polly P, Goldblatt J, Ward RL. Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5’UTR. Cancer Cell. 2011 Aug 16;20(2):200-213. https://www.cell.com/cancer-cell/fulltext/S1535-6108(11)00260-1.
- Hawkins NJ, Lee JH, Wong JJ, Kwok CT, Ward RL, Hitchins MP. MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa. Mod Pathol. 2009 Dec;22(12):1588-1599. https://www.nature.com/articles/modpathol2009130.
- Hitchins MP, Wong JJ, Suthers G, Suter CM, Martin DI, Hawkins NJ, Ward RL. Inheritance of a cancer-associated MLH1 germ-line epimutation. N Engl J Med. 2007 Feb 15;356(7):697-705. https://www.nejm.org/doi/full/10.1056/NEJMoa064522.
- Hitchins MP, Ward RL. Erasure of MLH1 methylation in spermatozoa-implications for epigenetic inheritance. Nat Genet.2007 Nov;39(11):1289. https://www.nature.com/articles/ng1107-1289.
- Hitchins MP, Lin VA, Buckle A, Cheong K, Halani N, Ku S, Kwok CT, Packham D, Suter CM, Meagher A, Stirzaker C, Clark S, Hawkins N, Ward RL. Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer. Cancer Res. 2007 Oct 1;67(19):9107-9116. https://aacrjournals.org/cancerres/article/67/19/9107/533444/Epigenetic-Inactivation-of-a-Cluster-of-Genes
- Hitchins M, Williams R, Cheong K, Halani N, Lin V, Packham D, Ku S, Buckle A, Hawkins N, Burn J, et al. MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. Gastroenterology. 2005 Nov;129(5):1392-1399. https://www.gastrojournal.org/article/S0016-5085(05)01787-7/fulltext.
Contact the Hitchins Lab
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Steven Spielberg Building, Room 119
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